Neuron
Volume 18, Issue 6, June 1997, Pages 1009-1023
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Article
Submillisecond AMPA Receptor-Mediated Signaling at a Principal Neuron–Interneuron Synapse

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Abstract

Glutamatergic transmission at a principal neuron–interneuron synapse was investigated by dual whole-cell patch-clamp recording in rat hippocampal slices combined with morphological analysis. Evoked EPSPs with rapid time course (half duration ≈ 4 ms; 34°C) were generated at multiple synaptic contacts established on the interneuron dendrites close to the soma. The underlying postsynaptic conductance change showed a submillisecond rise and decay, due to the precise timing of glutamate release and the rapid deactivation of the postsynaptic AMPA receptors. Simulations based on a compartmental model of the interneuron indicated that the rapid postsynaptic con-ductance change determines the shape and the somatodendritic integration of EPSPs, thus enabling interneurons to detect synchronous principal neuron activity.

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