Transcriptional control of the cell cycle

doi:10.1016/S0955-0674(96)80004-4

Current Opinion in Cell Biology

Volume 8, Issue 3, June 1996, Pages 318-324

https://doi.org/10.1016/S0955-0674(96)80004-4 Get rights and content

Abstract

Although a significant amount of evidence has demonstrated that there are intimate connections between transcriptional controls and cell cycle regulation, the precise mechanisms underlying these connections remain largely obscure. A number of recent advances have helped to define how critical cell cycle regulators, such as the retinoblastoma family of tumor suppressor proteins and the cyclin-dependent kinases, might function on a biochemical level and how such mechanisms of action have been conserved not only in the regulation of transcription by all three RNA polymerases but also across species lines. In addition, the use of in vivo techniques has begun to explain how the activity of the E2F transcription factor family is tied to the cell cycle dependent expression of target genes.

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Transcriptional control of the cell cycle

Abstract

Trends Genet

Genes Dev

Curr Opin Cell Biol

Nature

Cell

Genes Dev

pRb, p107 and the regulation of the E2F transcription factor

J Cell Sci

E2F-4, a new member of the E2F transcription factor family, interacts with p107

Genes Dev

E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle

Proc Natl Acad Sci USA

Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members

Genes Dev

E2F-5, a new E2F family member that interacts with p130 in vivo

Mol Cell Biol

The interaction of pRb with E2F inhibits the transcriptional activity of E2F

Genes Dev

Adenovirus E1a prevents the retinoblastoma gene product from repressing the activity of a cellular transcription factor

EMBO J

Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein

Mol Cell Biol

In vivo structure of the human cdc2 promoter: release of a p130-E2F-4 complex from sequences immediately upstream of the transcription initiation site coincides with induction of cdc2 expression

Mol Cell Biol

Protein-DNA interactions at the major and minor promoters of the divergently transcribed dhfr and rep3 genes during the Chinese hamster ovary cell cycle

Mol Cell Biol

An E2F-binding site mediates cell cycle-regulated repression of mouse B-myb transcription

EMBO J

HPV16 E7 oncoprotein deregulates B-myb expression: correlation with targetting of p107/E2F complexes

EMBO J

Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression

Genes Dev

Differential roles of two tandem E2F sites in repression of the human p107 promoter by retinoblastoma and p107 proteins

Mol Cell Biol

Periodic cdc25C transcription is mediated by a novell cell cycle-regulated repressor element (CDE)

EMBO J

Cell cycle regulation of the cyclin A, cdc25C and cdc2 genes is based on a common mechanism of transcriptional repression

EMBO J