Transducing signals of life and death

https://doi.org/10.1016/S0955-0674(97)80069-5Get rights and content

Abstract

The molecules that form signaling complexes with the cytoplasmic domains of tumor necrosis factor (TNF) receptors (TNF-Rs) and CD95 have been identified recently. The death-signaling pathways induced by TNF-R1 and CD95 involve a group of death domain containing proteins, including caspase-8, a member of the interleukin-1β-converting enzyme family. TNF-R1 and TNF-R2 also interact with the members of both the TNF-R associated factor family and the inhibitor of apoptosis protein family; these interactions lead to cell survival.

References (31)

  • TK Ishida et al.

    TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling

    Proc Natl Acad Sci USA

    (1996)
  • T Sato et al.

    FAP-1: a protein tyrosine phosphatase that associates with Fas

    Science

    (1995)
  • LA Tartaglia et al.

    The two different receptors for tumor necrosis factor mediate distinct cellular response

    Proc Natl Acad Sci USA

    (1991)
  • AM Chinnaiyan et al.

    Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95

    Science

    (1996)
  • T Kitson Raven et al.

    A death-domain-containing receptor that mediates apoptosis

    Nature

    (1996)
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