Transducing signals of life and death
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2015, Journal of Inorganic BiochemistryNitrosothiol signaling and protein nitrosation in cell death
2014, Nitric Oxide - Biology and ChemistryCitation Excerpt :This release triggers the formation of the apoptosome, which facilitates the enzymatic activation of caspase-9 [56,57] that subsequently activates executor caspases leading to apoptosis. The extrinsic pathway involves binding of death-inducing ligands such as Fas ligand (FasL) and tumor necrosis factor-α (TNF-α) to their respective receptors, resulting in the recruitment and activation of caspase-8 to the death-inducing signaling complex (DISC) by the Fas-associated death-domain (FADD)/TNFR1-associated death domain protein (TRADD) [58–61]. Activated caspase-8 leads to apoptosis directly through effector caspase-3.
The dynamics of soluble Fas/APO 1 apoptotic biochemical marker in acute ischemic stroke patients
2013, Advances in Medical SciencesCitation Excerpt :In the extrinsic pathway, caspase activation proceeds via Fas receptor (FasR), also known as apoptosis antigen 1 (APO-1). The Fas/Apo 1 receptor binding to its ligand (FasL) activates a number of intracellular proteins including procaspases, which trigger caspase activation by formation of the death-inducing signaling complex, resulting in neuronal death [15,16]. Soluble Fas/APO 1 (sFas/APO 1) is a soluble form of membrane protein of the TNF group, which prevents apoptosis by inhibiting the Fas/APO 1 to FasL binding reaction on the cell surface [17].