Agrin, laminin β2 (s-laminin) and ARIA: their role in neuromuscular development

doi:10.1016/S0959-4388(96)80014-6

Current Opinion in Neurobiology

Volume 6, Issue 1, February 1996, Pages 97-103

https://doi.org/10.1016/S0959-4388(96)80014-6 Get rights and content

Abstract

Development of pre- and postsynaptic specializations at the vertebrate neuromuscular junction is affected by molecules concentrated in the extracellular matrix of the synaptic cleft. Agrin, laminin β2 and ARIA are the best characterized proteins known to be involved in particular aspects of synaptic differentiation. Recent advances in defining the domains of these molecules that are crucial for their synapse-organizing activity and their localization to synaptic basal lamina will help our understanding of the molecular mechanisms involved in synapse formation.

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