Signalling through the neurotrophin receptor p75NTR
References (58)
- et al.
Expression and structure of the human NGF receptor
Cell
(1986) - et al.
Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system
Cell
(1992) - et al.
Early events in neurotrophin signalling via Trk and p75 receptors
Curr Opin Neurobiol
(1995) Ceramide: a potential second messenger in the nervous system
Mol Cell Neurosci
(1995)- et al.
Neurotrophins induce sphingomyelin hydrolysis — modulation by co-expression of p75NTR with Trk receptors
J Biol Chem
(1995) - et al.
Expression and possible function of nerve growth factor receptors on Schwann cells
Trends Neurosci
(1988) - et al.
Developmental regulation of full-length trkC in the rat sciatic nerve
Eur J Neurosci
(1995) Apoptosis — life-death balance within the cell
Science
(1996)- et al.
p75-deficient embryonic dorsal root sensory and neonatal sympathetic neurons display a decreased sensitivity to NGF
Development
(1994) - et al.
Neurotrophins and their p75 receptor
Cold Spring Harb Symp Quant Biol
(1996)
Modeled structure of the 75-kDa neurotrophin receptor
Protein Sci
CAR1, a TNFR-related protein, is a cellular receptor for cytopathic avian leukosis sarcoma viruses and mediates apoptosis
Cell
Apo-3, a new member of the tumor necrosis factor receptor family, contains a death domain and activates apoptosis and NF-kappaB
Curr Biol
A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen
J Biol Chem
A novel domain within the 55 kd TNF receptor signals cell death
Cell
Neurotrophins live and let die: does p75NTR decide?
Neuron
Gene transfer and molecular cloning of the rat nerve growth factor receptor: a new class of receptors
Nature
Functional interactions of neurotrophins and neurotrophin receptors
Annu Rev Neurosci
The Trk family of neurotrophin receptors
J Neurobiol
Physiology of the neurotrophins
Annu Rev Neurosci
Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor
Science
Modulation of growth and of morphological characteristics in glioma cells by nerve growth factor and glia maturation factor
Cancer Res
Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75
Nature
Neurotrophins stimulate the release of dopamine from rat mesencephalic neurons via Trk and p75Lntr receptors
J Biol Chem
Selective activation of NF-κB by nerve growth factor through the neurotrophin receptor p75
Science
Binding of brain-derived neurotrophic factor to the nerve growth factor receptor
Neuron
Binding of neurotrophin-3 to its neuronal receptors and interactions with nerve growth factor and brain-derived neutrophic factor
EMBO J
Activate NF-κB or die
Curr Biol
Induction of L1 mRNA in PC12 cells by NGF is modulated by cell—cell contact and does not require the high-affinity NGF receptor
J Neurosci
Cited by (206)
Growth factors and female reproduction in vertebrates
2024, Molecular and Cellular EndocrinologySeasonal expressions of nerve growth factor (NGF), and its receptor TrkA and p75 in the scent glands of muskrats (Ondatra zibethicus)
2024, Comparative Biochemistry and Physiology Part - B: Biochemistry and Molecular BiologyPartial ablation of frontal cortical subplate leads to developmental abnormalities in KCC2 in the prefrontal cortex
2022, Molecular and Cellular NeuroscienceCitation Excerpt :NGF binds its high-affinity receptor TrkA as well as its low-affinity receptor p75NTR (Bonhoeffer, 1996). During perinatal development, the subplate expresses p75NTR but not TrkA (Allendoerfer and Shatz, 1994), where NGF acting on p75NTR in the absence of TrkA promotes apoptosis of subplate neurons (Cabelli et al., 1996; Dechant and Barde, 1997; Niederhauser et al., 2000; Dechant and Barde, 2002). Infusions of NGF into the prefrontal subplate resulted in the manifestation of several features reminiscent of human schizophrenia, similar to what was seen in p75NTR receptor conjugated saporin-infused animals, such as loss of grey matter volume in the PFC and enlargement of lateral ventricles, as well as positive, negative, and cognitive symptom-like features (Desai et al., 2018; Lazar et al., 2008; Rajakumar et al., 2004; Rajakumar and Rajakumar, 2005).
Expression of nerve growth factor and its receptors in the uterus of rabbits: Functional involvement in prostaglandin synthesis
2016, Domestic Animal EndocrinologyCitation Excerpt :Nerve growth factor (NGF) has an essential role in survival, development, and differentiation of neurons in both central and peripheral systems [1]. Two receptors mediate the biological actions of this neurotrophin: the 140-kDa transmembrane tyrosin kinase receptor (neurotrophic tyrosine kinase receptor 1, [NTRK1]), characterized by high-affinity and specificity, and the low-affinity 75-kDa receptor (nerve growth factor receptor, [NGFR], previously known as p75), belonging to the family of tumor necrosis factor receptor [2–5]. After the initial discovery in the mouse sarcoma [6], NGF was found in a large array of tissues, including different organs of both male and female genital tract where it was supposed to influence key reproductive functions [7–11].
The epidermal Integrin beta-1 and p75NTR positive cells proliferating and migrating during wound healing produce various growth factors, while the expression of p75NTR is decreased in patients with chronic skin ulcers
2013, Journal of Dermatological ScienceCitation Excerpt :Collectively, the above results suggest that p75NTR+ cells affect wound healing process by producing some growth factors such as TGF-beta2 and VEGF-alpha. Other possible roles of p75NTR+ cells have been reported previously [16–20]. p75NTR molecule, a low-affinity neurotrophin receptor, is a member of the tumor necrosis factor receptor superfamily [21].