LTP and activity-dependent synaptogenesis: the more alike they are, the more different they become

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Abstract

Recent data suggest that long-term potentiation and activity-dependent synaptogenesis share the same mechanism at the initiation stage during which NMDA receptor activity is necessary to increase the postsynaptic response via AMPA receptor currents. However, several fundamental differences between the environments of young and mature synapses and the neurons that support them suggest that the same cellular mechanism is facilitated by very different parameters in the young versus the mature brain.

Abbreviations

AMPA α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid
CaM-KII Ca2+- and calmodulin-dependent kinase II
GABA γ-aminobutyric acid
LGN lateral geniculate nucleus
LTP long-term potentiation
NMDA N-methyl-D-aspartate
NO nitric oxide
NOS NO synthase

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