Current Biology
Volume 12, Issue 7, 2 April 2002, Pages 606-608
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Brief communications
Functional Integration of Adult-Born Neurons

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Over the past decade, it has become clear that neural stem cells in the adult mammalian brain continuously generate new neurons, predominantly in the hippocampus and olfactory bulb [1]. However, the central issue of whether these new neurons participate in functional synaptic circuitry has yet to be resolved. Here, we use virus-based transsynaptic neuronal tracing and c-Fos mapping of odor-induced neuronal activity to demonstrate that neurons generated in the adult functionally integrate into the synaptic circuitry of the brain.

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These authors contributed equally to this work.

6

Present address: Department of Microbiology-Immunology, Northwestern University Medical School, Chicago, Illinois 60611.