Current Biology
Volume 5, Issue 12, December 1995, Pages 1334-1338
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Synaptic Plasticity: A molecular mechanism for metaplasticity

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Abstract

The results of expressing a constitutive form of a prominent synaptic kinase in transgenic mice suggest how there can be a sliding threshold for synapse modification, an important element in some learning theories.

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Karl Deisseroth, Haruhiko Bito and Richard W. Tsien, Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Beckman Center B105A, Stanford, California 94305, USA.

Howard Schulman, Department of Neurobiology, Stanford University School of Medicine, Fairchild Building D221, Stanford, California 94305, USA.