Elsevier

Clinical Neurophysiology

Volume 110, Issue 6, 1 June 1999, Pages 1036-1040
Clinical Neurophysiology

Asynchronous pentobarbital-induced burst suppression with corpus callosum hemorrhage

https://doi.org/10.1016/S1388-2457(99)00046-2Get rights and content
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Abstract

Objective: We describe the electroencephalographic (EEG) findings in a 9-year-old girl, who presented with generalized tonic-clonic status epilepticus requiring pentobarbital anesthesia, and correlate these findings with clinicoradiologic evidence of a ruptured AVM with hemorrhage into the body of the corpus callosum.

Methods: EEG analysis accompanied by clinical assessment, CT and MRI scans, and cerebral angiography were performed.

Results: With pentobarbital coma, the EEG showed burst suppression with prominent interhemispheric asynchrony. Suppression epochs >2 s in duration and with amplitude <20 μV in all channels were identified. In 12 min of the EEG analyzed, 6 unilateral and 20 bilateral epochs occurred. Of the 20 bilateral suppression epochs, interhemispheric asynchrony of >1 s was noted at onset for 5 epochs and at offset for one. Chi-square analysis revealed an equal tendency for unilateral suppressions to occur over either hemisphere, and for suppression in one hemisphere to begin before the other.

Conclusions: We conclude that the corpus callosum plays a critical role in interhemispheric synchronization of cortical neuronal electrical activity and propose that: (1) normally, the corpus callosum modulates interhemispheric synchronization of cortical inhibition; and (2) with corpus callosal disruption, cortical areas are ‘released’ from such synchronization.

Keywords

Pentobarbital
Burst suppression
Corpus callosum
Status epilepticus

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