Archival ReportIncreased Binding of Peripheral Benzodiazepine Receptor in Alzheimer's Disease Measured by Positron Emission Tomography with [11C]DAA1106
Section snippets
Participants
The patients were recruited from the outpatient units of university-affiliated psychiatric hospitals and the psychiatric divisions of general hospitals. The healthy subjects were recruited among those participating in a community-based prospective cohort study performed in Ibaragi prefecture in Japan. Demographic and clinical data of the participants are presented in Table 1. We studied 10 healthy control subjects (3 women, 7 men) between 55 and 73 years old (67.9 ± 5.0 years; mean ± SD) and 10
Results
Mean %SUV images of a control subject and an AD patient are shown in Figure 2. Higher uptake of [11C]DAA1106 in the brain was observed in the AD patient compared with the aged normal subject.
The mean values of K1−k4 parameters across measured regions in control subjects and patients were .053 ± .005 and .049 ± .005 for K1, .073 ± .003 and .080 ± .005 for k2, .048 ± .002 and .053 ± .004 for k3, and .011± .001 and .010 ± .001 for k4, respectively. For K1−k4 values, ANOVA of each value for control
Discussion
In this study, [11C]DAA1106 binding to PBR was significantly increased in various regions in patients with AD at a relatively early stage. Providing that the affinity of radiotracer to PBR did not differ between the groups, our finding might be attributable to the higher number of PBR in these brain regions, which might reflect mainly the activated glial cells that were observed in the brain pathology of AD (8, 9).
Several confounding factors need to be considered. Firstly, patients with AD
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