Archival ReportReward Feedback Alterations in Unmedicated Schizophrenia Patients: Relevance for Delusions
Section snippets
Subjects and Instruments
Thirty subjects were included (15 unmedicated schizophrenia patients and 15 healthy volunteers matched for age, gender, and handedness). The schizophrenia patients (12 men; mean age: 30.1 ± 8.1 years) fulfilled DSM-IV and ICD-10 criteria for schizophrenia and had no other psychiatric axis I disorder (Structured Clinical Interview for DSM-IV [SCID]) (19) and no current drug abuse or past history of drug dependence (SCID interview and random urine drug testing). Eight patients were drug-naïve,
Behavioral Performance
There was a significant effect of cue type (reward, loss-avoidance, or neutral) on reaction times (F = 9.870; p = .001) but no significant main effect for group (F = 1.559; p = .223) nor a group × cue interaction (F = .349; p = .709). Post hoc t tests revealed faster responses in reward (healthy control subjects: t = 2.471, p = .028, and schizophrenia patients: t = 2.046, p = .060) and loss-avoidance trials (healthy control subjects: t = 3.250, p = .006, and schizophrenia patients: t = 2.526, p
Discussion
In the present study, we observed dysfunctional neural processing of reward feedback and reduced altered fronto-striatal connectivity in unmedicated patients with schizophrenia. Neural responses to reward feedback were differentially altered in two core regions of the reward system, the MPFC and the VS: in the MPFC, healthy control subjects showed reduction of brain activation during feedback of unsuccessful reward trials, which was reversed in schizophrenia patients (i.e., schizophrenia
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Authors FS and PS contributed equally to this work.