Research reportChronic brain hypoperfusion causes early glial activation and neuronal death, and subsequent long-term memory impairment
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Highlights
► Carotids were occluded with 1 week interval in the modified two-vessel occlusion. ► Modified 2VO causes long-term memory impairment. ► Neuronal damage and reactive astrogliosis happens in the acute phase. ► Cognitive behavior installed in stages more chronic of the model.
Keywords
chronic cerebral hypoperfusion
2VO-ischemia memory impairment
Memory impairment
Hippocampus
Glia
Neuron
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