Elsevier

Current Opinion in Cell Biology

Volume 36, October 2015, Pages 23-31
Current Opinion in Cell Biology

Filopodia in cell adhesion, 3D migration and cancer cell invasion

https://doi.org/10.1016/j.ceb.2015.06.007Get rights and content
Under a Creative Commons license
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This review discusses recent advances in our understanding of the role filopodia and filopodia-like structures in cell adhesion and three dimensional (3D) cell migration both in vitro and in vivo. In particular, we focus on recent advances demonstrating that filopodia are involved in substrate tethering and environment sensing in vivo. We further discuss the emerging role of filopodia and filopodial proteins in tumor dissemination as mounting in vitro, in vivo and clinical evidence suggest that filopodia drive cancer cell invasion and highlight filopodia proteins as attractive therapeutic targets. Finally, we outline outstanding questions that remain to be addressed to elucidate the role of filopodia during 3D cell migration.

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