Cell
Volume 120, Issue 4, 25 February 2005, Pages 545-555
Journal home page for Cell

Review
Twenty Years of the Alzheimer’s Disease Amyloid Hypothesis: A Genetic Perspective

https://doi.org/10.1016/j.cell.2005.02.008Get rights and content
Under an Elsevier user license
open archive

From Alois Alzheimer’s description of Auguste D.’s brain in 1907 to George Glenner’s biochemical dissection of β-amyloid in 1984, the “amyloid hypothesis” of Alzheimer’s disease has continued to gain support over the past two decades, particularly from genetic studies. Here we assess the amyloid hypothesis based on both known and putative Alzheimer’s disease genes.

Cited by (0)