Cell
Volume 141, Issue 7, 25 June 2010, Pages 1146-1158
ArticleLysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations
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Graphical Abstract
Highlights
► Presenilin-1 (PS1) is essential for lysosomal acidification and protein degradation ► v-ATPase V0a1 subunit glycosylation and delivery to lysosomes requires PS1 ► PS1 mutations impair lysosomal acidification and protein turnover by autophagy ► Neurons in PS1-deficient mice have lysosomal acidification deficits
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Present address: Taub Institute, Columbia University, New York, NY 10032, USA
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Present address: Institute of Neuropathology, IDIBELL-Hospital Universitari de Bellvitge, Hospitalet de Llobregat, 80907 Barcelona, Spain
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Present address: Department of Anatomy, Canadian Memorial Chiropractic College, Toronto, Ontario M4G 3E6, Canada
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