Letter to the Editor

Selective reorienting response of the left hemisphere to invalid visual targets in the right side of space: Relevance for the spatial neglect syndrome

Experimental and theoretical studies have tried to gain insights into the involvement of the Temporal Parietal Junction (TPJ) in a broad range of cognitive functions like memory, attention, language, self-agency and theory of mind. Recent investigations have demonstrated the partition of the TPJ in discrete subsectors. Nonetheless, whether these subsectors play different roles or implement an overarching function remains debated. Here, based on a review of available evidence, we propose that the left TPJ codes both matches and mismatches between expected and actual sensory, motor, or cognitive events while the right TPJ codes mismatches. These operations help keeping track of statistical contingencies in personal, environmental, and conceptual space. We show that this hypothesis can account for the participation of the TPJ in disparate cognitive functions, including “humour”, and explain: a) the higher incidence of spatial neglect in right brain damage; b) the different emotional reactions that follow left and right brain damage; c) the hemispheric lateralisation of optimistic bias mechanisms; d) the lateralisation of mechanisms that regulate routine and novelty behaviours. We propose that match and mismatch operations are aimed at approximating “free energy”, in terms of the free energy principle of decision-making. By approximating “free energy”, the match/mismatch TPJ system supports both information seeking to update one's own beliefs and the pleasure of being right in one's own' current choices. This renewed view of the TPJ has relevant clinical implications because the misfunctioning of TPJ-related “match” and “mismatch” circuits in unilateral brain damage can produce low-dimensional deficits of active-inference and predictive coding that can be associated with different neuropsychological disorders.

We explored the effects of parietal damage on inhibitory effects of visuospatial attention, inhibition of return (IOR) and inhibitory tagging (IT), in the vertical meridian. We combined a vertical spatial cue paradigm with a Stroop task employing three different temporal intervals between the spatial cue and the target (700, 1200 and 2000 ms) in two groups of patients, one with damage to the parietal cortex and underlying white matter (the parietal patients group) and the other with damage in other brain areas not including the parietal lobe (the control patient group), and a healthy control group. Healthy controls showed the expected inhibitory effects, IOR at the 700 and 1200 intervals and IT at the 1200 interval (as evidenced in a reduction in the magnitude of Stroop interference at the cued location). On the other hand, only the group of parietal patients showed delayed onset of inhibitory effects, IOR and IT appeared at the 1200 ms and 2000 ms intervals, respectively. These findings provide evidence for a role of the parietal cortex, and the underlying fibre tracts, in inhibitory processing in the vertical meridian, with damage to the parietal cortex altering the time course of attention-dependent inhibition.

In the human brain, the temporal-parietal junction (TPJ) is a histologically heterogenous area that includes the ventral portions of the parietal cortex and the caudal superior temporal gyrus sector adjacent to the posterior end of the Sylvian fissure. The anatomical heterogeneity of the TPJ is matched by its seemingly ubiquitous involvement in different cognitive functions that span from memory to language, attention, self-consciousness, and social behavior. In line with established clinical evidence, recent fMRI investigations have confirmed relevant hemispheric differences in the TPJ function. Most importantly, the same investigations have highlighted that, in each hemisphere, different subsectors of the TPJ are putatively involved in different cognitive functions. Here I review empirical evidence and theoretical proposals that were recently advanced to gain a unifying interpretation of TPJ function(s). In the final part of the review, a new overarching interpretation of the TPJ function is proposed. Current advances in cognitive neuroscience can provide important insights that help improve the clinical understanding of cognitive deficits experienced by patients with lesions centered in or involving the TPJ area.

The temporoparietal junction (TPJ) and related areas are activated when a target stimulus appears at unexpected locations in Posner's spatial-cueing paradigm, and also when deviant stimuli are presented within a series of standard events in oddball paradigms. This type of activation corresponds to the ventral attention network (VAN), for regions defined on the basis of the spatial task. However, involvement of the VAN in object-based updating of attention has rarely been examined. In the present study, we used functional magnetic resonance imaging to investigate brain responses to (i) invalid targets after category-cueing and (ii) neutrally cued targets deviating in category from the background series of pictures. Bilateral TPJ activation was observed in response to invalidly cued targets, as compared to neutrally cued targets. Reference to the main large-scale brain networks showed that peaks of this activation located in the angular gyrus and inferior parietal lobule belonged to the default mode (DMN) and fronto-parietal networks (FPN), respectively. We found that VAN regions were involved only for simple detection activity. We conclude that spatial and non-spatial reorienting of attention rely on different network underpinnings. Our data suggest that DMN and FPN activity may support the ability to disengage from contextually irrelevant information.

The present review covers the latest findings on the lateralization of the dorsal and ventral attention systems, their functional specialization, and their clinical relevance for stroke-induced attentional dysfunction. First, the original assumption of a bilateral dorsal system for top-down attention and a right-lateralized ventral system for stimulus-driven attention is critically reviewed. The evidence for the involvement of the left parietal cortex in attentional functions is discussed and findings on putative pathways linking the dorsal and ventral network are presented. In the second part of the review, we focus on the different attentional subsystems and their lateralization, discussing the differences between spatial, feature- and object-based attention, and motor attention. We also review studies based on predictive coding frameworks of attentional functions. Finally, in the third section, we provide an overview of the consequences of specific disruption within the attention networks after stroke. The role of the interhemispheric (im)balance is discussed, and the results of new promising therapeutic approaches employing brain stimulation techniques such as transcranial magnetic stimulation (TMS) or transcranial direct current stimulation (tDCS) are presented.