Indirubin-3′-oxime inhibits c-Jun NH2-terminal kinase: anti-apoptotic effect in cerebellar granule neurons
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Acknowledgments
Mingtao Li was supported by the National Natural Science Foundation of China: nos. 30170299 and 30370450; the Natural Science Foundation of Guangdong Province: nos. 010697, 021803, and 2003A3080402; and the major project grants from the Department of Science and Technology in Guangzhou: nos. 2002Z3-E4031 and 2003Z2-E4081. Zixu Mao was supported by NIH RO1 HD39446 and RO1 NS048254.
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Indirubin 3′-Oxime Inhibits Migration, Invasion, and Metastasis In Vivo in Mice Bearing Spontaneously Occurring Pancreatic Cancer via Blocking the RAF/ERK, AKT, and SAPK/JNK Pathways
2019, Translational OncologyCitation Excerpt :In mouse fibroblast NIH/3T3, Indox inhibited the fibroblast growth factor-induced phosphorylation of ERK and AKT, but did not inhibit the phosphorylation of JNK and p38 MAPK [33]. Meanwhile, Indox has been reported to directly inhibit the activity of JNK1 and JNK3 in neuronal cells [34]. Similar to our findings, 5NO2Indox showed inhibitory effects on the phosphorylation of RAF-1, ERK, JNK, and c-Jun, thereby blocking the neoplastic transformation of mouse epidermal cells [35].
Indirubin, a bis-indole alkaloid binds to tubulin and exhibits antimitotic activity against HeLa cells in synergism with vinblastine
2018, Biomedicine and PharmacotherapyCitation Excerpt :Indirubin (INR) and its derivatives have shown anticancer effects on different cancer cell lines like PC3, HepG2, HCT116, HeLa, A549, NCI-H358, MDA-MB-468, and MDA-MB-435 [2,6–9]. Indirubin has been reported to modulate cellular targets like aryl hydrocarbon receptor [10,11], glycogen synthase kinase-3 [12], glycogen phosphorylase b [13], c-Jun N-terminal kinase [14], the Stat3 transcription factor [15], and DNA synthesis [2]. Inhibition of several kinases involved in cell division was reasoned for the possible G2/M phase arrest induced by indirubin and its analogues in cancer cells [2,7,8].
Physicochemical characterization and in vitro permeation of an indirubin derivative
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2011, Neuroscience Letters