Attenuated fever response in mice lacking TRPV1
Section snippets
Acknowledgements
The authors thank J. Wang for expert technical assistance and members of the Caterina lab for valuable discussion. Supported by grants from The W.M. Keck Foundation, The Searle Scholars Program, The Arnold and Mabel Beckman Foundation and Dainippon Pharmaceuticals to M.J.C.
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Cited by (93)
The Contribution of the Ankyrin Repeat Domain of TRPV1 as a Thermal Module
2020, Biophysical JournalCitation Excerpt :The latter has been evidenced from studies in which the deletion of TRPV1 in mice alters noxious and mild temperature sensation (6,7), whereas knockout of other thermo-TRPs such as TRPV2, TRPV3, and TRPV4 shows little effect in sensory transduction in rodents (6,8,9). Moreover, whereas deletion of TRPV1 in rodents does not affect corporal temperature, blockage of TRPV1 in vivo triggers hyperthermia (10). The rat TRPV1 structure is a tetramer (Fig. 1 a), with every monomer consisting of 838 amino acids (Fig. 1 c).
The contribution of TRPV1 channel to 20-HETE—Aggravated ischemic neuronal injury
2018, Prostaglandins and Other Lipid MediatorsAfferent pathways for autonomic and shivering thermoeffectors
2018, Handbook of Clinical NeurologyMolecular basis of peripheral innocuous cold sensitivity
2018, Handbook of Clinical NeurologyTRPV1 participates in the activation of clock molecular machinery in the brown adipose tissue in response to light-dark cycle
2017, Biochimica et Biophysica Acta - Molecular Cell ResearchCitation Excerpt :The amplitude of core temperature of TrpV1 KO mice is higher in comparison to WT animals [25,79,83]. On the other hand, Iida et al. [39] did not find a relationship between the lack of TRPV1 and the amplitude of core temperature. These controversial data have been found in studies with genetically modified animals; in contrast, unequivocal results have been obtained with a pharmacological approach, demonstrating a clear involvement of TRPV1 channel in the core body temperature: TRPV1 agonist causes hypothermia while an antagonist causes hyperthermia [26,63], corroborating what we and others have found in TrpV1 KO mice.
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These authors contributed equally to this study.