Effects of riluzole and flufenamic acid on eupnea and gasping of neonatal mice in vivo
Section snippets
Acknowledgements
This work was supported by Conacyt-42870, México. We greatly appreciate the very constructive comments from the reviewers. We also thank A.I. Gutierrez-Lerma for revising the English manuscript and José Rodolfo Fernández and Arturo Franco for technical assistance.
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Perinatal inflammation and gestational intermittent hypoxia disturbs respiratory rhythm generation and long-term facilitation in vitro: Partial protection by acute minocycline
2022, Respiratory Physiology and NeurobiologyCitation Excerpt :Moreover, combined experimental and modeling experiments have shown that a variety of intrinsic and synaptic changes, within the preBötC, contribute to changes in respiratory rhythm regularity (Carroll and Ramirez, 2013; Guerrier et al., 2015), phenomena that can certainly be modulated by neuroinflammation (Peña-Ortega, 2019b). It is important to consider that while excessive variability may indicate instability in the preBötC (Peña and Aguileta, 2007; Tryba et al., 2006), insufficient variability could also result in its inability to adapt to changing demands (Carroll and Ramirez, 2013; Fietkiewicz et al., 2016; Juárez-Vidales et al., 2021). Data will be made available on request.
A high concentration of sevoflurane induces gasping breaths in mice
2020, Respiratory Physiology and NeurobiologyCitation Excerpt :In this context. there is evidence to show that gasping can be eliminated by administration of drugs such as ‘riluzole’ that inhibit conductance through persistent sodium channels in vivo study (Paton et al., 2006; Peña and Aguileta, 2007). Concerning the hypoxia-induced gasping, there is evidence to show that hypoxia disrupts the respiratory oscillator which depends on reciprocal inhibitory synaptic activity (Richter et al., 1991) with an involvement of neuromodulatory mechanisms (Richter et al., 1999), and thus in the face of severe hypoxia, failure of inhibitory synaptic transmission causes disinhibition of medullary mechanisms.
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2020, Respiratory Physiology and NeurobiologyRespiratory neuron characterization reveals intrinsic bursting properties in isolated adult turtle brainstems (Trachemys scripta)
2016, Respiratory Physiology and NeurobiologyThe physiological determinants of Sudden Infant Death Syndrome
2013, Respiratory Physiology and NeurobiologyCitation Excerpt :During a prolonged hypoxic challenge, i.e., when sighs fail to arouse the infant or if it is impossible for the infant to escape the re-breathing condition, breathing stereotypically transitions from a state of eupnea to gasping (Fig. 1, (Hunt, 1992; Poets et al., 1999; Harper et al., 2000)). Gasping is characterized by periodic short breaths with fast rise and fall times (Cherniack et al., 1971; Richter et al., 1991; Hunt, 1992; Poets et al., 1999; Harper et al., 2000; Pena and Aguileta, 2007), and, similar to sighs, gasping produces changes in heart rate (Hunt, 1992; Poets et al., 1999; Harper et al., 2000). The gasping behavior can be considered a mechanism of last resort capable of inducing auto-resuscitation during a hypoxic challenge (Hunt, 1992; Poets et al., 1999; Harper et al., 2000).