Minocycline does not affect amyloid β phagocytosis by human microglial cells
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Acknowledgements
We thank the Netherlands Brain Bank (coordinator Dr. R. Ravid) for supplying the human CNS tissue, and Mrs. M Jacobs for technical assistance.
This study was supported by grants from Alzheimer Nederland (V-2000-008) and from the Internationale Stichting Alzheimer Onderzoek (ISAO grant: 03509) and stichting Dioraphte.
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2022, Ageing Research ReviewsCitation Excerpt :Minocycline is a semisynthetic tetracycline that has anti-inflammatory properties (Garrido-Mesa et al., 2013). Studies reported that minocycline could considerably decrease the levels of various proinflammatory cytokines including TNF-α and IL-6 secreted from astrocytes (Garwood et al., 2010; Familian et al., 2007). Treatment with minocycline decreased tau aggregation in the cortex region of the htau mouse model and diminished amyloid pathology in primary cortical neurons (Noble et al., 2009).
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