ZD 7288 inhibits T-type calcium current in rat hippocampal pyramidal cells
Section snippets
Acknowledgements
This research was supported by the DGICYT (BFU2004-00869 and SAF2007-61361).
References (17)
- et al.
ZD 7288 inhibits low-threshold Ca2+ channel activity and regulates sperm function
Biochem. Biophys. Res. Commun.
(2003) - et al.
Isolation of neurons suitable for patch-clamping from adult mammalian central nervous systems
J. Neurosci. Meth.
(1986) - et al.
H-current: properties of a neuronal and network pacemaker
Neuron
(1998) - et al.
Characterization of rebound depolarization in hippocampal neurons
Biochem. Biophys. Res. Commun.
(2006) - et al.
Inhibitory actions of ZENECA ZD 7288 on whole-cell hyperpolarization activated inward current (If) in guinea-pig dissociated sinoatrial node cells
Br. J. Pharmacol.
(1993) - et al.
Properties of ivabradine-induced block of HCN1 and HCN4 pacemaker channels
J. Physiol.
(2006) ZD 7288 inhibits postsynaptic glutamate receptor-mediated responses at hippocampal perforant path-granule cell synapses
Eur. J. Neurosci.
(2004)- et al.
Assessing the role of Ih channels in synaptic transmission and mossy fiber LTP
Proc. Natl. Acad. Sci. U.S.A.
(2002)
Cited by (78)
HCN channels and absence seizures
2023, Neurobiology of DiseaseRole of hyperpolarization-activated cyclic nucleotide-gated channel HCN2 in embryonic neural stem cell proliferation and differentiation
2022, Neurochemistry InternationalConjunctive changes in multiple ion channels mediate activity-dependent intrinsic plasticity in hippocampal granule cells
2022, iScienceCitation Excerpt :Such activation of two-pore domain potassium channels could potentially explain the time dependent reduction in Rin we observed. In addition, there are known non-specificities of ZD7288 (Chen, 2004; Chevaleyre and Castillo, 2002; Sanchez-Alonso et al., 2008), Ba2+ (Zhou et al., 2012), which constitute well-established limitations of the use of pharmacological agents (discussed in the context of DG granule cells in (Mishra and Narayanan, 2021a)). However, in our study, we have also employed a constellation of physiological measurements showing signature physiological changes (Figures 1, 2, 3, and 4) to provide lines of evidence for roles of the different ion channels in the reported form of plasticity.
The funny current: Even funnier than 40 years ago. Uncanonical expression and roles of HCN/f channels all over the body
2021, Progress in Biophysics and Molecular BiologyI<inf>h</inf> from synapses to networks: HCN channel functions and modulation in neurons
2021, Progress in Biophysics and Molecular BiologyDopamine Deficiency Reduces Striatal Cholinergic Interneuron Function in Models of Parkinson's Disease
2019, NeuronCitation Excerpt :For experiments using DA receptor ligands, the antagonists were bath-applied for 5 min prior to recording a baseline. As the HCN channel blocker ZD7288 (4-ethylphenylamino-1,2-dimethyl-6-methylaminopyrimidinium chloride; 50 μM) reportedly changes spike width (Bennett et al., 2000) and inhibits Ca2+ (Sánchez-Alonso et al., 2008) and Na+ channel currents (Wu et al., 2012), it was used to validate experiments using Cs+. Synaptic blockers were not generally used since ChIs receive minimal synaptic input in the slice preparation and DA and muscarinic receptors have an undetectable effect on firing rates in vitro (Bennett and Wilson, 1999).