Suppression of enriched environment-induced neurogenesis in a rodent model of neuropathic pain
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Pain Relief Reverses Hippocampal Abnormalities in Trigeminal Neuralgia
2022, Journal of PainCitation Excerpt :Previous studies have reported altered adult hippocampal neurogenesis (AHN) in animal models of chronic pain.34,100 Specifically, several studies have reported that neuropathic pain negatively affects neurogenesis22,24,82,93, and other persistent pain conditions are related to decreases in AHN.4,26,70 In line with these previous findings, the current study and our previous investigation reported significant bilateral volume loss in the CA4, DG, and ML HP in TN patients – all of which considered primary hippocampal subfields involved in AHN.99
Microglia dependent BDNF and proBDNF can impair spatial memory performance during persistent inflammatory pain
2020, Behavioural Brain ResearchA comprehensive literature review of chronic pain and memory
2018, Progress in Neuro-Psychopharmacology and Biological PsychiatryCitation Excerpt :Some changes in functional connectivity between these regions have also been observed and, in particular, an increased connectivity between the thalamus and the posterior hippocampus or a decrease in the global connectivity of the superior parietal lobule (Mansour et al., 2016). Some internal changes including impaired short-term plasticity or decreased neurogenesis in the hippocampus have also been observed in animal models of neuropathic pain (Mutso et al., 2012; Ren et al., 2011; Terada et al., 2008). These hippocampal cell modifications would appear to be directly related to the cognitive and emotional problems observed in these animal models.
In vivo evaluation of the hippocampal glutamate, GABA and the BDNF levels associated with spatial memory performance in a rodent model of neuropathic pain
2017, Physiology and BehaviorCitation Excerpt :The hippocampus is a crucial memory-processing region of the brain, also responsible for modulating the transmission of pain. Recent investigations have independently reported hippocampus dysfunctions in animal models of chronic pain, including short-term memory deficits, abnormal cytokine expression, deficits in long-term potentiation (LTP), impaired enriched-environment neurogenesis and instability of the hippocampal CA1 place cells [6–11]. Additionally, the disruptive capacities of pain on memory in a visual encoding tasks and the reduction in hippocampal volume in elderly patients with chronic pain have been reported [5,12].
Are the emergence of affective disturbances in neuropathic pain states contingent on supraspinal neuroinflammation?
2016, Brain, Behavior, and ImmunityAssociations of limbic-affective brain activity and severity of ongoing chronic arthritis pain are explained by trait anxiety
2016, NeuroImage: ClinicalCitation Excerpt :The left hippocampal CBF-VAS association was independent of catastrophizing whilst the right hippocampus became non-significant when controlling for catastrophizing scores. The hippocampus is a region typically known for the role it plays in memory and the limbic system, but it has also been observed to develop significant molecular changes such as decreased plasticity and neurogenesis in animal models of chronic neuropathic pain (Terada et al., 2008; Mutso et al., 2012). Human imaging studies have also reported increased hippocampal activity during ongoing OA pain (Howard et al., 2012; Parks et al., 2011) and in chronic back pain patients when compared with controls (Mutso et al., 2014).