Quantification of short-term slow wave sleep homeostasis and its disruption by minocycline in the laboratory mouse
Research highlights
▶ Novel analysis reveals short term (<30 min) slow wave sleep homeostasis in mice. ▶ Non-rapid eye movement sleep EEG power increases significantly after >80% of time spent awake in 20 min. ▶ Non-rapid eye movement sleep EEG power decreases significantly after >80% of time spent in SWS in 20 min. ▶ This EEG response to wake is attenuated by anti-neuroinflammatory agent minocycline.
Section snippets
Acknowledgements
These studies were supported by a Washington State University, Spokane Faculty Seed Grant. We thank Paul Franken for insightful comments on the manuscript.
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