Rapid CommunicationSubtype-specific reduction of olfactory bulb interneurons in Pax6 heterozygous mutant mice
Section snippets
Acknowledgements
We thank Dr. Sarah Maxwell for critical reading of the manuscript, and Ms Ayumi Ogasawara, Sayaka Makino and Makiko Hoshino for technical assistance and animal cares. This work was supported by Tohoku Neuroscience Global COE Program “Basic and Translational Research Center for Global Brain Science” from MEXT of Japan (to N.O.), and Core Research for Evolutional Science and Technology from Japan Science and Technology Agency (to N.O.).
References (30)
- et al.
Properties of external plexiform layer interneurons in mouse olfactory bulb slices
Neuroscience
(2005) - et al.
Fate mapping of the mouse prosencephalic neural plate
Dev. Biol.
(2000) - et al.
Chemically defined neuron groups and their subpopulations in the glomerular layer of the rat main olfactory bulb
Neurosci. Res.
(1995) - et al.
How simple is the organization of the olfactory glomerulus?: the heterogeneity of so-called periglomerular cells
Neurosci. Res.
(1998) - et al.
Heterogeneity of parvalbumin-containing neurons in the mouse main olfactory bulb, with special reference to short-axon cells and betaIV-spectrin positive dendritic segments
Neurosci. Res.
(2008) - et al.
Neurotrophin receptor-mediated death of misspecified neurons generated from embryonic stem cells lacking Pax6
Cell. Stem Cell
(2007) - et al.
Molecular identity of olfactory bulb interneurons: transcriptional codes of periglomerular neuron subtypes
J. Mol. Histol.
(2007) - et al.
Chemical characterization of Pax6-immunoreactive periglomerular neurons in the mouse olfactory bulb
Cell. Mol. Neurobiol.
(2009) - et al.
The distinct temporal origins of olfactory bulb interneuron subtypes
J. Neurosci.
(2008) - et al.
Brain-derived neurotrophic factor selectively regulates dendritogenesis of parvalbumin-containing interneurons in the main olfactory bulb through the PLCgamma pathway
J. Neurobiol.
(2006)
Genetic dissection of Pax6 dosage requirements in the developing mouse eye
Hum. Mol. Genet.
Olfactory bulb development is altered in small-eye (Sey) mice
J. Comp. Neurol.
How the olfactory system makes sense of scents
Nature
Neuronal fate determinants of adult olfactory bulb neurogenesis
Nat. Neurosci.
Mouse small eye results from mutations in a paired-like homeobox-containing gene
Nature
Cited by (28)
Structural and functional consequences of PAX6 mutations in the brain: Implications for aniridia
2021, Brain ResearchCitation Excerpt :This finding is similar to other studies of olfactory bulb volume in Pax6-deficient mice (Dellovade et al., 1998). In yet another study of Pax6-deficient mice, parvalbumin positive interneurons in the external plexiform layer of the olfactory bulb were dramatically and selectively reduced (Haba et al., 2009), which could be responsible for the volumetric decrease observed in our study, as well as offer a potential explanation for reductions in volume in the human olfactory bulb. The cortex showed no change in this study; however, the cerebellum showed age-related decreases in volume.
The role of Pax6 in brain development and its impact on pathogenesis of autism spectrum disorder
2019, Brain ResearchCitation Excerpt :In the adult rodent brain, Pax6 expression persists in the subventricular zone of the lateral ventricle and in the subgranular zone of the dentate gyrus in the hippocampus (Hevner et al., 2006; Kohwi et al., 2005; Maekawa et al., 2005; Nacher et al., 2005). Pax6 expression is detected in neurons within the olfactory bulb, the amygdala, the pallidum, the thalamus, the hypothalamus, the midbrain, and the cerebellum (Haba et al., 2009; Hack et al., 2005). A recent study by Duan et al. (2013) reported that nearly 40% of Pax6-positive cells in the cortex are neurons.
Osterix is dispensable for the development of the mouse olfactory bulb
2016, Biochemical and Biophysical Research CommunicationsCitation Excerpt :Fibroblast growth factor/fibroblast growth factor receptor 1 signaling is necessary for olfactory bulb morphogenesis [3]. Pax6 is expressed in dopaminergic and GABAergic periglomerular cells [4,5], and assists in embryonic olfactory interneuron formation [6]. Dlx1 and Dlx2 transcription factors are also characterized in GABAergic interneurons, to promote cell differentiation, migration, and survival [7].
Reduced proliferation and excess astrogenesis of Pax6 heterozygous neural stem/progenitor cells
2012, Neuroscience ResearchCitation Excerpt :We have previously shown that the proliferation of NSPCs in the SGZ and production of neurons in the dentate gyrus is reduced in the postnatal hippocampus of Pax6 heterozygous mutant (rSey2/+) rats (Maekawa et al., 2005). Our laboratory and others have also reported that the number of interneurons in the postnatal olfactory bulb is decreased in Pax6 heterozygous mutant (Sey/+) mice, suggesting that Sey/+ mice have defects in production of interneurons from the postnatal NSPCs in the SVZ (Haba et al., 2009; Hack et al., 2005; Kohwi et al., 2005). However, the proliferation and differentiation of Pax6 heterozygous NSPCs are not examined in detail.
Co-expression and Interaction of Pax6 with Genes and Proteins of Immunological Surveillance in the Brain of Mice
2022, Neurotoxicity ResearchAnalysis of Islet-1, Nkx2.1, Pax6, and Orthopedia in the forebrain of the sturgeon Acipenser ruthenus identifies conserved prosomeric characteristics
2022, Journal of Comparative Neurology