Intrinsic connections of the cingulate cortex in the rat suggest the existence of multiple functionally segregated networks
Section snippets
Experimental procedures
Fifty-five female Wistar rats (weight: 180–220 g; Harlan Central Proefdier Bedrijf, Zeist, the Netherlands) were used in this study. All experiments were approved by the Animal Ethical Committee of the Vrije Universiteit concerned with ethical aspects of experiments and care for laboratory animals and were in accordance with national and EC guidelines. Care was taken to minimize the number of animals and their suffering as much as possible.
Cytoarchitectonics and flat map
Both the AC and RS can be divided into a ventral (ACv/RSv) and a dorsal (ACd/RSd) area. The RSv can be further subdivided into a ventral and dorsal part (RSv-a and RSv-b, respectively). The infralimbic cortex (IL), prelimbic cortex (PL) and AC lack a granular layer IV and are therefore referred to as agranular cortex (Uylings and Van Eden, 1990). The present description of cytoarchitectonic criteria of the cingulate cortex focuses on characteristic differences between the different subregions
Cytoarchitectonic map
A considerable variation appears to exist in the nomenclature for equivalent areas of the rodent cingulate cortex. The AC in the present study is equivalent to Brodmann’s area 24, whereas the RS can be equated with his area 29 (Brodmann, 1909). The RS is often referred to as the posterior cingulate cortex. In order to provide more clarity, a comparison between the nomenclature in this study with that of other major cytoarchitectonic studies in rodents is provided in Table 2 (Brodmann 1909, Rose
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