Behavioural neuroscienceMemory consolidation and reconsolidation of an inhibitory avoidance task in mice: Effects of a new different learning task
Section snippets
Experimental animals
CF-1 male mice (FUCAL, Buenos Aires, Argentina) were used (age: 60–70 days; weight: 25–30g). They were individually identified and housed in stainless-steel cages, 15 per cage. The mice were kept in a climatized animal room (21–23°C) maintained on a 12-h light/dark cycle (lights on 06:00 h), with ad libitum access to dry food and tap water. Experiments were carried out in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals (NIH Publication No.
Results
Training step-through latencies differences among all the groups used in these experiments were not significant (TSTL=10 (8–2) s; H(19)=4.20; P>0.05).
Discussion
The results of the first series of experiments indicate that the immediate exposure to a potential new learning situation (nose-poke habituation) after the acquisition of a one-trial inhibitory avoidance, impaired retention performance of the original learning. The effect was observed across three consecutive retention test sessions, and was not seen if the exposure to the habituation learning task was carried out 3 h after the avoidance training. These results are, in general, similar to those
Acknowledgments
This work was supported by grant B028 from the University of Buenos Aires. M.G.B. is a fellow from (UBA). M.M.B., G.B.A. and C.M.B. are members of CONICET.
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2014, Neurobiology of Learning and MemoryCitation Excerpt :The present results are congruent with studies that used an inhibitory avoidance task and found differential effects of OF as a function of timing of presentation. OF did not affect performance when given before training, yet it had enhancing and deteriorating effects when applied before and after the test, respectively (Blake et al., 2011; Boccia et al., 2005; Izquierdo & McGaugh, 1985, 1987). Evidence from several experiments indicates that adrenal stress hormones, released during or after emotionally arousing experiences, play a critical role in consolidating lasting memories (McGaugh & Roozendaal, 2002).
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2014, Journal of Physiology ParisCitation Excerpt :As an animal trained with a weak footshock frequently enter the dark compartment in about 120 s during the reactivation session, this training condition allows memory to be either enhanced or impaired, and favors the development of extinction processes. On the other hand, animals trained with a strong footshock do not enter into the dark compartment during the reactivation session, thus impairing – or at least limiting – the development of extinction phenomena (Blake et al., 2012; Boccia et al., 2003, 2004, 2005, 2006, 2010); so, the use of a strong footshock favors the observation of impairing effects of interventions. Control over-reinforced mice (those trained with a strong footshock) can really extinguish their avoidance memory, but need several successive extinction trials, and show spontaneous recovery (Baratti et al., 2008).
Hippocampal α<inf>7</inf>-nicotinic cholinergic receptors modulate memory reconsolidation: A potential strategy for recovery from amnesia
2013, Neurobiology of Learning and MemoryCitation Excerpt :In this case, all the mice performed during T1 with retention latencies at the ceiling (300 s). Exposure to the HB immediately after T1 led to memory impairment in T2, confirming previous results (Boccia et al., 2005). The post-T2 administration of Ch in the hippocampus allowed recovery of the impaired memory in the mice exposed to the HB, and caused memory impairment in the non-exposed mice (Figs. 6 and 7).
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Both authors contributed equally to the work.