Brief ReportMorphological changes in dendritic spines of Purkinje cells associated with motor learning
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Acknowledgments
We thank Dr. William T. Greenough for critically reading the manuscript and comments; electron microscopy team at Korea Basic Science Institute (KBSI, Daejeon, Republic of Korea); Scott P. Herrick, Sang Hoon Lee, and In Sung Park for their valuable contributions to this research. This work was supported by the Korea Research Foundation Grant funded by the Korean Government (MOEHRD, Basic Research Promotion Fund) (KRF-2006-E0008) and partly supported by the cooperating program of the National
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2022, Current Research in NeurobiologyMotor learning rapidly increases synaptogenesis and astrocytic structural plasticity in the rat cerebellum
2021, Neurobiology of Learning and MemoryCitation Excerpt :In male rats, thin spines were elevated on all six days of training, reaching statistical significance on days 1, 3, and 6 (González-Tapia et al., 2017). Thin spines were also increased after 26 days of acrobatic training (González-Tapia, Velázquez-Zamora, Olvera-Cortés, & González-Burgos, 2015; Lee, Jung, Arii, Imoto, & Rhyu, 2007), along with mushroom and stubby spines (González-Tapia et al., 2015). We did not find a significant difference in Purkinje cell spine circumference after four days of acrobatic training, although the circumference of the spines did tend to be reduced in the AC group.
Response learning stimulates dendritic spine growth on dorsal striatal medium spiny neurons
2018, Neurobiology of Learning and MemoryCitation Excerpt :That is, training initially stimulates dendritic spine growth and maturation, but these measures regress back to the control state even with continued training (Knafo, Libersat, & Barkai, 2005; O’Malley, O'Connell, Murphy, & Regan, 2000). The majority of studies, however, have demonstrated that increases in spine growth and maturation with learning persist over time (González-Tapia et al., 2015; Ibias et al., 2015; Kuhlman et al., 2014; Lee, Jung, Arii, Imoto, & Rhyu, 2007; Ma et al., 2016; Moser et al., 1994; Uriarte, Ogundele, & Pardo, 2017). Regardless of the persistence of spine changes over time, several lines of evidence suggest that new dendritic spine growth and associated new synapses are substrates for learning and memory formation in other brain regions, including the hippocampus, neocortex, and cerebellum.
Preventive motor training but not progenitor grafting ameliorates cerebellar ataxia and deregulated autophagy in tambaleante mice
2017, Neurobiology of DiseaseCitation Excerpt :Interestingly, they show that the impact of motor training and BDNF upregulation diverges in WT and mutant mice, indicating that outcomes strongly depend on contextual tissue conditions. Based on evidence that environmental stimulation modulates the density of synaptic contacts on PCs (Kim et al., 2002; Lee et al., 2007), we asked whether motor activity could influence afferents and efferents connections implicated in the deterioration of motor performances in mutant mice. To gain a degree of understanding into changes elicited by motor training, we focused on lobule II where PC survival was the maximum, and analysed excitatory inputs from parallel and climbing fibers to PCs as well as PC spine densities.
- 1
Present address: Department of Pharmacology, Georgetown University Medical School, Washington, DC 20057, USA.
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Present address: Protein Therapeutics Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-333, Republic of Korea.