Original articleMeta-analysis of Medical Intervention for Normal Tension Glaucoma
Section snippets
Materials and Methods
This meta-analysis was performed according to a predetermined protocol describing complete and detailed methods, which followed a previous publication.8
Results
The selection flow of studies is summarized in Figure 1. The literature search identified 420 articles; including 35 randomized clinical trials that evaluate medical intervention in the treatment of NTG. Twenty randomized clinical trials were excluded for reasons that included 9 duplicate publications, 1 meeting abstract, 1 treated with latanoprost 0.006% twice daily, 4 without measure outcomes, and 5 with follow-up more than 3 months. Thus, 15 randomized clinical trials that met our inclusion
Discussion
This meta-analysis confirmed that latanoprost, bimatoprost, timolol, and brimonidine significantly reduced IOP in patients with NTG. The highest reduction in IOP at peak was achieved by brimonidine (24%), followed by bimatoprost, latanoprost, timolol, dorzolamide, brinzolamide, and betaxolol (12%). At trough, the order is latanoprost (20%), bimatoprost, timolol, dorzolamide, and brimonidine (11%). The order at diurnal curve is latanoprost (20%), bimatoprost, timolol, and brimonidine (16%).
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Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.