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The Neurobiology of Moral Behavior: Review and Neuropsychiatric Implications

Published online by Cambridge University Press:  07 November 2014

Mario F. Mendez
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Abstract

Morality may be innate to the human brain. This review examines the neurobiological evidence from research involving functional magnetic resonance imaging of normal subjects, developmental sociopathy, acquired sociopathy from brain lesions, and frontotemporal dementia. These studies indicate a “neuromoral” network for responding to moral dilemmas centered in the ventromedial prefrontal cortex and its connections, particularly on the right. The neurobiological evidence indicates the existence of automatic “prosocial” mechanisms for identification with others that are part of the moral brain. Patients with disorders involving this moral network have attenuated emotional reactions to the possibility of harming others and may perform sociopathic acts. The existence of this neuromoral system has major clinical implications for the management of patients with dysmoral behavior from brain disorders and for forensic neuropsychiatry.

Type
Review Articles
Information
CNS Spectrums , Volume 14 , Issue 11 , November 2009 , pp. 608 - 620
Copyright
Copyright © Cambridge University Press 2009

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References

REFERENCES

1.Haidt, J. The new synthesis in moral psychology. Science. 2007;316:998–1002.CrossRefGoogle ScholarPubMed
2.Wilson, JO. The Moral Sense. New York, NY: Simon & Schuster; 1993.Google Scholar
3.Hauser, MD. Moral Minds: How Nature Designed our Universal Sense of right and Wrong. New York, NY: Ecco/Harper Collins; 2006.Google Scholar
4.Moll, J, de Oliveira-Souza, R, Eslinger, PJ. Morals and the human brain: a working model. Neuroreport. 2003;14:299–305.Google Scholar
5.Moll, J, Zahn, R, de Oliveira-Souza, R, Krueger, F, Grafman, J. Opinion: the neural basis of human moral cognition. Nat Rev Neurosci. 2005;6:799–809.CrossRefGoogle ScholarPubMed
6.Berthoz, S, Grezes, J, Armony, JL, Passingham, RE, Dolan, RJ. Affective response to one's own moral violations. Neuroimage. 2006;31:945–950.Google Scholar
7.De Waal, FB. How animals do business. Sci Am. 2005;292:54–61.Google Scholar
8.Haidt, J. The emotional dog and its rational tail: A social intuitionist approach to moral judgment. Psychol Rev. 2001;108:814–834.Google Scholar
9.Hauser, MD, Cushman, FA, Young, LL. A dissociation between moral judgments and justifications. Mind Language. 2006;22:1–21.CrossRefGoogle Scholar
10.Fiske, AP. Moral emotions provide the self-control needed to sustain social relationships. Self Identity. 2002;1:169–175.CrossRefGoogle Scholar
11.Tangney, JP, Stuewig, J, Mashek, DJ. Mirror neuron system: basic findings and clinical applications. Ann Neurol. 2007;62:213–218.Google Scholar
12.Moll, J, Schulkin, J. Social attachment and aversion in human moral cognition. Neurosci Biobehav Rev. 2009;33:456–465.Google Scholar
13.Pinker, S. The moral instinct. The New York Times Magazine. January 13, 2008.Google Scholar
14.Greene, JD, Sommerville, RB, Nystrom, LE, Darley, JM, Cohen, JD: An fMRI investigation of emotional engagement in moral judgment. Science. 2001;293:2105–2108Google Scholar
15.Cosmides, L, Tooby, J, Fiddick, L, Bryant, GA. Detecting cheaters. Trends Cogn Sci. 2005;9:505–506Google Scholar
16.Moll, J, Oliveira-Souza, R, Eslinger, PJ, et al.The neural correlates of moral sensitivity: a functional magnetic resonance imaging investigation of basic and moral emotions. J Neurosci. 2002;22:2730–2736.CrossRefGoogle ScholarPubMed
17.Schaich Borg, J, Hynes, C, Van Horn, J, Grafton, S, Sinnott-Armstrong, W. Consequences, action, and intention as factors in moral judgments: an FMRI investigation. J Cogn Neurosci. 2006;18:803–817.CrossRefGoogle ScholarPubMed
18.Greene, JD, Nystrom, LE, Engell, AD, Darley, JM, Cohen, JD. The neural bases of cognitive conflict and control in moral judgment. Neuron. 2004;44:389–400.CrossRefGoogle ScholarPubMed
19.Heekeren, HR, Wartenburger, I, Schmidt, H, Schwintowski, HP, Villringer, A. An fMRI study of simple ethical decision-making. Neuroreport. 2003;14:1215–1219.CrossRefGoogle ScholarPubMed
20.D'Argembeau, A, Xue, G, Lu, ZL, Van der Linden, M, Bechara, A. Neural correlates of envisioning emotional events in the near and far future. Neuroimage. 2008;40:398–407.Google Scholar
21.Damasio, AR. Descartes' Error: Emotion, Reason, and the Human Brain. New York, NY: Putnam; 1994.Google Scholar
22.Moll, J, de Oliveira-Souza, R. Moral judgments, emotions and the utilitarian brain. Trends Cogn Sci. 2007;11:319–321.Google Scholar
23.Moll, J, De Oliveira-Souza, R, Zahn, R. The neural basis of moral cognition: sentiments, concepts, and values. Ann NY Acad Sci. 2008;1124:161–180.CrossRefGoogle ScholarPubMed
24.Baxter, MG, Parker, A, Lindner, CC, Izquierdo, AD, Murray, EA. Control of response selection by reinforcer value requires interaction of amygdala and orbital prefrontal cortex. J Neurosci. 2000;20:4311–4319.Google Scholar
25.Roelofs, K, Minelli, A, Mars, RB, van Peer, J, Toni, I. On the neural control of social emotional behavior. Soc Cogn Affect Neurosci. 2009;4:50–58.Google Scholar
26.Rolls, ET, Hornak, J, Wade, D, McGrath, J. Emotion-related learning in patients with social and emotional changes associated with frontal lobe damage. J Neurol Neurosurg Psychiatry. 1994;57:1518–1524.Google Scholar
27.Adolphs, R, Tranel, D, Damasio, AR. The human amygdala in social judgment. Nature. 1998;393:470–474.Google Scholar
28.Luo, Q, Nakic, M, Wheatley, T, Richell, R, Martin, A, Blair, RJ. The neural basis of implicit moral attitude–an IAT study using event-related fMRI. Neuroimage. 2006;30:1449–1457.Google Scholar
29.Hsu, M, Anen, C, Quartz, SR. The right and the good: distributive justice and neural encoding of equity and efficiency. Science. 2008;320:1092–1095.CrossRefGoogle ScholarPubMed
30.Harenski, CL, Hamann, S. Neural correlates of regulating negative emotions related to moral violations. Neuroimage. 2006;30:313–324.Google Scholar
31.Singer, T, Kiebel, SJ, Winston, JS, Dolan, RJ, Frith, CD. Brain responses to the acquired moral status of faces. Neuron. 2004;41:653–662.Google Scholar
32.Robertson, D, Snarey, J, Ousley, O, et al.The neural processing of moral sensitivity to issues of justice and care. Neuropsychologia. 2007;45:755–766.Google Scholar
33.Takahashi, H, Lato, M, Matsuura, M, Mobbs, D, Suhara, T, Okubo, Y. When your gain is my pain and your pain is my gain: Neural correlates of envy and schadenfreude. Science. 2009;323:937–939.Google Scholar
34.Frith, CD, Frith, U. The neural basis of mentalizing. Neuron. 2006;50:531–544.Google ScholarPubMed
35.Young, L, Saxe, R. The neural basis of belief encoding and integration of moral judgment. Neuroimage. 2008;40:1912–1920.Google Scholar
36.Young, L, Cushman, F, Hauser, M, Saxe, R. The neural basis of the interaction between theory of mind and moral judgment. Proc Nat Acad Sci. 2007;104:8235–8240.Google Scholar
37.Schaefer, A, Collette, F, Philippot, P, et al.Neural correlates of “hot” and “cold” emotional processing: a multilevel approach to the functional anatomy of emotion. Neuroimage. 2003;18:938–949.Google Scholar
38.Zahn, R, Moll, J, Krueger, F, Huey, ED, Garrido, G, Grafman, J. Social concepts are represented in the superior anterior temporal cortex. Proc Nat Acad Sci. 2007;104:6430–6435.Google Scholar
39.Decety, J, Jackson, PL. The functional architecture of human empathy. Behav Cogn Neurosci Rev. 2004;3:71–100.Google Scholar
40.Heekeren, HR, Wartenburger, I, Schmidt, H, Prehn, K, Schwintowski, HP, Villringer, A. Influence of bodily harm on neural correlates of semantic and moral decision-making. Neuroimage. 2005;24:887–897.Google Scholar
41.Waldemann, MR, Dieterich, JH. Throwing a bomb on a person versus throwing a person on a bomb: intervention myopia in moral intuitions. Psychol Sci. 2007;18:247–253.Google Scholar
42.Young, L, Saxe, R. An fMRI investigation of Spontaneous Mental State Inference for Moral judgment. J Cogn Neurosci. 2009;21:1396–1405.Google Scholar
43.Zahn, R, Moll, J, Iyengar, V, et al.Social conceptual impairments in frontotemporal lobar degeneration with right anterior temporal hypometabolism. Brain. 2009;132:604–616.Google Scholar
44.Takahashi, H, Kato, M, Matsuura, M, et al.Neural correlates of human virtue judgment. Cerebral Cortex. 2008;18:1886–1891.Google Scholar
45.Greene, J, Haidt, J. How (and where) does moral judgment work? Trends Cogn Sci. 2002;6:517–523.CrossRefGoogle ScholarPubMed
46.Greene, J. From neural ‘is’ to moral ‘ought’: what are the moral implications of neuroscientific moral psychology? Nat Rev Neurosci. 2003;4:846–849.CrossRefGoogle ScholarPubMed
47.Greene, JD. Why are VMPFC patients more utilitarian? A dual-process theory of moral judgment explains. Trends Cogn Sci. 2007;11:322–323.Google Scholar
48.Nichols, S, Mallon, R. Moral dilemmas and moral rules. Cognition. 2006;100:530–542.Google Scholar
49.Prehn, K, Wartenberger, I, Mériau, K, et al.Individual differences in moral judgment competence influence neural correlates of socio-normative judgments. Soc Cogn Affect Neurosci. 2008;2:33–46.Google Scholar
50.Miller, G. Neurobiology. The roots of morality. Science. 2008;320:734–737.CrossRefGoogle ScholarPubMed
51.De Quervain, DJ-F, Fischbacher, U, Treyer, V, et al.The neural basis of altruistic punishment. Science. 2004;305:1254–1258.CrossRefGoogle ScholarPubMed
52.Tabibnia, G, Satpute, AB, Lieberman, MD. The sunny side of fairness: preference for fairness activates reward circuitry (and disregarding unfairness activates self-control circuitry). Psychol Sci. 2008;19:339–347.Google Scholar
53.Talmi, D, Frith, C. Neurobiology–feeling right about doing right. Nature. 2007;446:865–866.Google Scholar
54.Kliemann, D, Young, L, Scholz, J, Saxe, R. The influence of prior record on moral judgment. Neuropsychologia. 2008;46:2949–2957.Google Scholar
55.Amodio, DM, Frith, CD. Meeting of minds: the medial frontal cortex and social cognition. Nat Rev Neurosci. 2006;7:268–277.Google Scholar
56.Knoch, D, Nitsche, MA, Fischbacher, U, Eisenegger, C, Pascual-Leone, A, Fehr, E. Studying the neurobiology of social interaction with transcranial direct current stimulation--the example of punishing unfairness. Cereb Cortex. 2008;18:1987–1990.Google Scholar
57.Bechara, A, Damasio, H, Damasio, AR. Emotion, decision making and the orbitofrontal cortex. Cereb Cortex. 2000;10:295–307.Google Scholar
58.Zahn, R, Moll, J, Paiva, M, et al.The neural basis of human social values: evidence from functional MRI. Cerebr Cortex. 2009;19:276–283.CrossRefGoogle ScholarPubMed
59.Blair, RJR. The roles of orbital frontal cortex in the modulation of antisocial behavior. Brain Cogn. 2004;55:198–208.Google Scholar
60.Blair, J, Mitchell, D, Blair, K. The Psychopath. Emotion and the Brain. Oxford, England: Blackwell Publishing; 2005.Google Scholar
61.Blair, RJ. Applying a cognitive neuroscience perspective to the disorder of psychopathy. Dev Psychopathol. 2005;17:865–891.Google Scholar
62.Bird, CM, Castelli, F, Malik, O, Frith, U, Husain, M. The impact of extensive medial frontal lobe damage on ‘Theory of Mind’ and cognition. Brain. 2004;127:914–928.CrossRefGoogle ScholarPubMed
63.Berthoz, S, Armony, JL, Blair, RJ, Dolan, RJ. An fMRI study of intentional and unintentional (embarrassing) violations of social norms. Brain. 2002;125:1696–1708.Google Scholar
64.De Waal, FB. Putting the altruism back into altruism: the evolution of empathy. Annu Rev Psychol. 2007;59:1–22.Google Scholar
65.Shamay-Tsoory, SG, Aharon-Peretz, J, Perry, D. Two systems for empathy: a double dissociation between emotional and cognitive empathy in inferior frontal gyrus versus ventromedial prefrontal lesions. Brain. 2009;132:617–627.Google Scholar
66.Eslinger, PJ. Neurological and neuropsychological bases of empathy. Eur Neurol. 1998;39:193–199.CrossRefGoogle ScholarPubMed
67.Gallese, V. Before and below ‘theory of mind’: embodied simulation and the neural correlates of social cognition. Philos Trans R Soc Lond B Biol Sci. 2007;362:659–669.CrossRefGoogle ScholarPubMed
68.Shamay-Tsoory, SG, Tomer, R, Berger, BD, Aharon-Peretz, J. Characterization of empathy deficits following prefrontal brain damage: the role of the right ventromedial prefrontal cortex. J Cogn Neurosci. 2003;15:324–337.Google Scholar
69.Singer, T. The neuronal basis and ontogeny of empathy and mind reading: review of literature and implications for future research. Neurosci Biobehav Rev. 2006;30:855–863.Google Scholar
70.Carr, L, Iacoboni, M, Dubeau, M-C, Mazziotta, JC, Lenzi, JL. Neural mechanisms of empathy in humans: a relay from neural systems for imitation to limbic areas. Proc Natl Acad Sci USA. 2003;100:5497–5502.Google Scholar
71.Nummenmaa, L, Hirvonen, J, Parkkola, R, Hietanen, JK. Is emotional contagion special? An fMRI study on neural systems for affective and cognitive empathy. Neuroimage. 2008;43:571–580.Google Scholar
72.Mitchell, JP, Banaji, MR, Macrae, CN. The link between social cognition and self-referential thought in the medial prefrontal cortex. J Cogn Neurosci. 2005;17:1306–1315.Google Scholar
73.Iacoboni, M, Mazziotta, JC. Mirror neuron system: basic findings and clinical applications. Ann Neurol. 2007;62:213–218.Google Scholar
74.Rizzolatti, G, Fabbri-Destro, M. The mirror system and its role in social cognition. Curr Opin Neurobiol. 2008;18:179–184.CrossRefGoogle ScholarPubMed
75.Oberman, LM, Pineda, JA, Ramachandran, VS. The human mirror neuron system: A link between action observation and social skills. Soc Cogn Affect Neurosci. 2007;2:62–66.Google Scholar
76.Preston, SD, de Waal, FB. Empathy: Its ultimate and proximate bases. Behav Brain Sci. 2002;25:1–20.Google Scholar
77.Schulte-Ruther, M, Markowitsch, HJ, Fink, GR, Piefke, M. Mirror neuron and theory of mind mechanisms involved in face-to-face interactions: a functional magnetic resonance imaging approach to empathy. J Cogn Neurosci. 2007;19:1354–1372.Google Scholar
78.Kaplan, JT, Iacoboni, M. Getting a grip on other minds: mirror neurons, intention understanding, and cognitive empathy. Soc Neurosci. 2006;1:175–183.Google Scholar
79.Kédia, G, Berthoz, S, Wessa, M, Hilton, D, Martinot, JL. An agent harms a victim: a functional magnetic resonance imaging study on specific moral emotions. Cogn Neurosci. 2008;20:1788–1798.Google Scholar
80.Lamm, C, Batson, CD, Decety, J. The neural substrate of human empathy: effects of perspective-taking and cognitive appraisal. J Cogn Neurosci. 2007;19:42–58.Google Scholar
81.Lieberman, MD. Social cognitive neuroscience: a review of core processes. Ann Rev Psychol. 2007;58:259–289.Google Scholar
82.Schilbach, L, Wohlschlaeger, AM, Kraemer, NC, et al.Being with virtual others: neurological correlates of social interaction. Neuropsychologia. 2006;44:718–730.Google Scholar
83.Markowitsch, HJ. Neuroscience and crime. Neurocase. 2008;14:1–6.Google Scholar
84.Intrator, J, Hare, R, Stritzke, P, et al.A brain imaging (single photon emission computerized tomography) study of semantic and affective processing in psychopaths. Biol Psychiatry. 1997;42:96–103.Google Scholar
85.Levenston, GK, Patrick, CJ, Bradley, MM, Lang, PJ. The psychopath as observer: emotion and attention in picture processing. J Abnorm Psychol. 2000;109:373–385.Google Scholar
86.Raine, A, Buchsbaum, M, LaCasse, L. Brain abnormalities in murderers indicated by positron emission tomography. Biol Psychiatry. 1997;42:495–508.Google Scholar
87.Blake, PY, Pincus, JH, Buckner, C. Neurologic abnormalities in murderers. Neurology. 1995;45:1641–1647.Google Scholar
88.Wong, MT, Lumsden, J, Fenton, GW, Fenwick, PB. Electroencephalography, computed tomography and violence ratings of male patients in a maximum-security mental hospital. Acta Psychiatr Scand. 1994;90:97–101.Google Scholar
89.Critchley, HD, Simmons, A, Daly, EM, et al.Prefrontal and medial temporal correlates of repetitive violence to self and others. Biol Psychiatry. 2000;47:928–934.CrossRefGoogle ScholarPubMed
90.Ishikawa, SS, Raine, A, Lencz, T, Bihrle, S, Lacasse, L. Autonomic stress reactivity and executive functions in successful and unsuccessful criminal psychopaths from the community. J Abnorm Psychol. 2001;110:423–432.Google Scholar
91.Krakowski, M, Czobor, P, Carpenter, MD, et al.Community violence and inpatient assaults: neurobiological deficits. J Neuropsychiatry Clin Neurosci. 1997;9:549–555.Google Scholar
92.LaPierre, D, Braun, CMJ, Hodgins, S. Ventral frontal deficits in psychopathy: neuropsychological test findings. Neuropsychologia. 1995;33:139–151.Google Scholar
93.Moffitt, TE. Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy. Psychol Rev. 1993;100:674–701.Google Scholar
94.Raine, A, Meloy, JR, Bihrle, S, Stoddard, J, LaCasse, L, Buchsbaum, MS. Reduced prefrontal and increased subcortical brain functioning assessed using positron emission tomography in predatory and affective murderers. Behav Sci Law. 1998;16:319–332.Google Scholar
95.Seidenwurm, D, Pounds, TR, Globus, A, Valk, PE. Abnormal temporal lobe metabolism in violent subjects: correlation of imaging and neuropsychiatric findings. Am J Neuroradiol. 1997;18:625–631.Google Scholar
96.Soderstrom, H, Hultin, L, Tullberg, M, Wikkelso, C, Ekholm, S, Forsman, A. Reduced frontotemporal perfusion in psychopathic personality. Psychiatry Res. 2002;114:81–94.Google Scholar
97.Hoptman, MJ. Neuroimaging studies of violence and antisocial behavior. J Psychiatr Pract. 2003;9:265–278.Google Scholar
98.De Oliveira-Souza, R, Hare, RD, Bramati, IE, et al.Psychopathy as a disorder of the moral brain: fronto-temporo-limbic grey matter reductions demonstrated by voxelbased morphometry. Neuroimage. 2008;40:1202–1213.Google Scholar
99.Tiihonen, J, Rossi, R, Laakso, MP, et al.Brain anatomy of persistent violent offenders: more rather than less. Psychiatry Res. 2008;163:201–212.Google Scholar
100.Raine, A, Lencz, T, Bihrle, S, LaCasse, L, Colletti, P. Reduced prefrontal gray matter volume and reduced autonomic activity in antisocial personality disorder. Arch Gen Psychiatry. 2000;57:119–127.Google Scholar
101.Sapolsky, RM, The frontal cortex and the criminal justice system. Philos Trans R Soc Lond B Biol Sci. 2004;359:1787–1796.Google Scholar
102.De Brito, SA, Mechelli, A, Wilke, M, et al.Size matters: Increased grey matter in boys with conduct problems and callous-unemotional traits. Brain. 2009;132:843–852.Google Scholar
103.Veit, R, Flor, H, Erb, M, et al.Brain circuits involved in emotional learning in antisocial behavior and social phobia in humans. Neurosci Lett. 2002;328:233–236.Google Scholar
104.Finger, EC, Marsh, AA, Mitchell, DG, et al.Abnormal ventromedial prefrontal cortex function in children with psychopathic traits during reversal learning. Arch Gen Psychiatry. 2008;65:586–594.Google Scholar
105.Blair, RJ. The amygdala and ventromedial prefrontal cortex in morality and psychopathy. Trends Cogn Sci. 2007;11:387–392.Google Scholar
106.Cohen, L, Angladette, L, Benoit, N, Pierrot-Deseilligny, C. A man who borrowed cars. Lancet. 1999;353:34.CrossRefGoogle Scholar
107.Paradiso, S, Robinson, RG, Arndt, S. Self-reported aggressive behavior in patients with stroke. J Nerv Ment Dis. 1996;184:746–753.Google Scholar
108.Pillmann, F, Rohde, A, Ullrich, S, Draba, S, Sannemüller, U, Marneros, A. Violence, criminal behavior, and the EEG: significance of left hemispheric focal abnormalities. J Neuropsychiatry Clin Neurosci. 1999;11:454–457.Google Scholar
109.Anderson, SW, Bechara, A, Damasio, H, Tranel, D, Damasio, AR. Impairment of social and moral behavior related to early damage in human prefrontal cortex. Nat Neurosci. 1999;2:1031–1037.Google Scholar
110.Eslinger, PJ, Flaherty-Craig, CV, Benton, AL. Developmental outcomes after early prefrontal cortex damage. Brain Cogn. 2004;55:84–103.CrossRefGoogle ScholarPubMed
111.Bechara, A, Tranel, D, Damasio, H. Characterization of the decision-making deficit of patients with ventromedial prefrontal cortex lesions. Brain. 2000;123:2189–2202.Google Scholar
112.Bechara, A, Damasio, AR, Damasio, H, Anderson, SW. Insensitivity to future consequences following damage to human prefrontal cortex. Cognition. 1994;50:7–15.Google Scholar
113.Blair, RJR, Cipolotti, L. Impaired social response reversal. A case of ‘acquired sociopathy’. Brain. 2000;123:1122–1141.Google Scholar
114.Ciaramelli, E, Muccioli, M, Ladavas, E, di Pellegrino, G. Selective deficit in personal moral judgment following damage to ventromedial prefrontal cortex. Soc Cogn Affect Neurosci. 2007;2:84–92.Google Scholar
115.Cushman, FA, Young, LL, Hauser, MD. The role of conscious reasoning and intuition in moral judgments: Testing three principles of permissible harm. Psychol Sci. 2006;17:1082–1089.CrossRefGoogle Scholar
116.Damasio, AR, Tranel, D, Damasio, H. Individuals with sociopathic behavior caused by frontal damage fail to respond autonomically to social stimuli. Behav Brain Res. 1990;41:81–94.Google Scholar
117.Koenigs, M, Young, L, Adolphs, R, Tranel, D, Cushman, F, Hauser, M, Damasio, A. Damage to the prefrontal cortex increases utilitarian moral judgments. Nature. 2007;446:908–911.Google Scholar
118.Shamay-Tsoory, SG, Tomer, R, Berger, BD, Goldsher, D, Aharon-Peretz, J. Impaired “affective theory of mind” is associated with right ventromedial prefrontal damage. Cogn Behav Neurol. 2005;18:55–67.Google Scholar
119.Tranel, D, Bechara, A, Denburg, NL. Asymmetric functional roles of right and left ventromedial prefrontal cortices in social conduct, decision-making, and emotional processing. Cortex. 2002;38:589–612.CrossRefGoogle ScholarPubMed
120.Tranel, D. “Acquired sociopathy”: the development of sociopathic behavior following focal brain damage. Prog Exp Pers Psychopathol Res. 1994;285–311.Google Scholar
121.Beer, JS, Heerey, EA, Keltner, D, Scabini, D,. Knight, RT. The regulatory function of self-conscious emotion: Insights from patients with orbitofrontal damage. J Pers Soc Psychol. 2003;85:594–604.Google Scholar
122.Beer, JS, John, OP, Scabini, D, Knight, RT. Orbitofrontal cortex and social behavior: integrating self-monitoring and emotion-cognition interactions. J Cong Neurosci. 2006;18:871–879.Google ScholarPubMed
123.Eslinger, PJ, Grattan, LM, Damasio, AF. Developmental consequences of childhood frontal lobe damage. Arch Neurol. 1992;49:764–769.Google Scholar
124.Shamay-Tsoory, SG, Tibi-Elhanany, Y, Aharon-Peretz, J. The green-eyed monster and malicious joy: the neuroanatomical bases of envy and gloating (schadenfreude). Brain. 2007;130:1663–1678.Google Scholar
125.Lough, S, Hodges, JR. Measuring and modifying abnormal social cognition in frontal variant frontotemporal dementia. J Psychosom Res. 2002;53:639–646.Google Scholar
126.Scarpa, A, Raine, A. Psychophysiology of anger and violent behavior. Psychiatr Clin North Am. 1997;20:375–394.Google Scholar
127.Zlotnick, C. Antisocial personality disorder, affect dysregulation and childhood abuse among incarcerated women. J Personal Disord. 1999;13:90–95.Google Scholar
128.Brower, MC, Price, BH. Neuropsychiatry of frontal lobe dysfunction in violent and criminal behaviour: a critical review. J Neurol Neurosurg Psychiatry. 2001;71:720–726.Google Scholar
129.Koenigs, M, Tranel, D. Irrational economic decision-making after ventromedial prefrontal damage: evidence from the ultimatum game. J Neurosci. 2007;21:951–956.CrossRefGoogle Scholar
130.Anderson, SW, Barrash, J, Bechara, A, Tranel, D. Impairments of emotion and realword complex behavior following childhood- or adult-onset damage to ventromedial prefrontal cortex. J Int Neuropsychol Soc. 2006;12:224–235.CrossRefGoogle ScholarPubMed
131.Burgess, PW, Alderman, N, Forbes, C, et al.The case for the development and use of “ecologically valid” measures of executive functions in experimental and clinical neuropsychology. J Int Neuropsychol Soc. 2006;12:194–209.Google Scholar
132.Saver, JL, Damasio, AR. Preserved access and processing of social knowledge in a patient with acquired sociopathy due to ventromedial frontal damage. Neuropsychologia. 1991;29:1241–1249.Google Scholar
133.Barrash, J, Tranel, D, Anderson, SW. Acquired personality disturbances associated with bilateral damage to the ventromedial prefrontal region. Develop Neuropsychol. 2000;18:355–381.Google Scholar
134.Bechara, A, Van Der Linden, M. Decision-making and impulse control after frontal lobe injuries. Curr Opin Neurol. 2005;18:734–739.Google Scholar
135.Camille, N, Coricelli, G, Sallet, J, Pradat-Diehl, P, Duhamel, JR, Sirigu, A. The involvement of the orbitofrontal cortex in the experience of regret. Science. 2004;304:1167–1170.Google Scholar
136.Lough, S, Kipps, CM, Treise, C, Watson, P, Blair, JR, Hodges, JR. Social reasoning, emotion and empathy in frontotemporal dementia. Neuropsychologia. 2006;44:950–958.Google Scholar
137.Mah, LW, Arnold, MC, Grafman, J. Deficits in social knowledge following damage to ventromedial prefrontal cortex. J Neuropsychiatry Clin Neurosci. 2005;17:66–74.Google Scholar
138.Neary, D, Snowden, J, Gustafson, L, et, al, Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology. 1998;51:1546–1552.Google Scholar
139.Miller, BL, Chang, L, Mena, I, Boone, K, Lesser, IM. Progressive right frontotemporal degeneration: clinical, neuropsychological and SPECT characteristics. Dementia 1993;4:204–213.Google Scholar
140.Edwards-Lee, T, Miller, BL, Benson, DF, et al.The temporal variant of frontotemporal dementia. Brain. 1997;120:1027–1040.Google Scholar
141.Mychack, P, Kramer, JH, Boone, KB, Miller, BL. The influence of right frontotemporal dysfunction on social behavior in frontotemporal dementia. Neurology. 2001;56(Suppl 4):S11–S15.Google Scholar
142.Perry, RJ, Rosen, HR, Kramer, JH, Beer, JS, Levenson, RL, Miller, BL. Hemispheric dominance for emotions, empathy and social behaviour: Evidence from right and left handers with frontotemporal dementia. Neurocase. 2001;7:145–160.Google Scholar
143.Mendez, MF, Lim, GTH. Alterations in the sense of ‘humanness’ in right hemisphere predominant FTD patients. Cogn Behav Neurol. 2004;17:133–138.Google Scholar
144.Mendez, MF, Lauterbach, E, Sampson, S, ANPA Committee on Research. An Evidence-Based Review of the Psychopathology of Frontotemporal Dementia: A Report of the ANPA Committee on Research. J Neuropsychiatry Clin Neurosci. 2008;20:130–149.Google Scholar
145.Mendez, MF, Chen, AK, Shapira, JS, Miller, BL. Acquired sociopathy and frontotemporal dementia. Dement Geriatr Cogn Disord. 2005;20:99–104.Google Scholar
146.Gustafson, L. Clinical picture of frontal lobe degeneration of non-Alzheimer type. Dementia. 1993;4:143–148.Google Scholar
147.Lynch, T, Sano, M, Marder, KS, et al.Clinical characteristics of a family with chromosome 17-linked disinhibition-dementia-parkinsonism-amyotrophy complex. Neurology. 1994;44:1878–1884.Google Scholar
148.Miller, BL, Darby, A, Benson, DF, Cummings, JL, Miller, MH. Aggressive, socially disruptive and antisocial behaviour associated with fronto-temporal dementia. Br J Psychiatry. 1997;170:150–154.Google Scholar
149.Mendez, MF, Chow, T, Ringman, J, Twitchell, G, Hinkin, CH. Pedophilia and disturbances of the temporal lobes. J Neuropsychiatry Clin Neurosci. 2000;12:71–76.Google Scholar
150.Mendez, MF, Anderson, E, Shapira, JS. An investigation of moral judgment in frontotemporal dementia. Cogn Behav Neural. 2005;18:193–197.Google Scholar
151.Rankin, KP, Kramer, JH, Miller, BL. Patterns of cognitive and emotional empathy in frontotemporal lobar degeneration. Cogn Behav Neurol. 2005;18:28–36.Google ScholarPubMed
152.Rankin, KP, Kramer, JH, Mychack, P, Miller, BL. Double dissociation of social functioning in frontotemporal dementia. Neurology. 2003;60:266–271.Google Scholar
153.Rankin, KP, Rosen, HJ, Kramer, JH, et al.Right and left medial orbitofrontal volumes show an opposite relationship to agreeableness in FTD. Dement Geriatr Cogn Disord. 2004;17:328–332.Google Scholar
154.Gorno-Tempini, ML, Rankin, KP, Woolley, JD, Rosen, HJ, Phengrasamy, L, Miller, BL. Cognitive and behavioral profile in a case of right anterior temporal lobe neurodegeneration. Cortex. 2004;40:631–644.Google Scholar
155.Rankin, KP, Gorno-Tempini, ML, Allison, SC, et al.Structural anatomy of empathy in neurodegenerative disease. Brain. 2006;129:2945–2956.Google Scholar
156.Snowden, JS, Gibbons, ZC, Blackshaw, A, et al.Social cognition in frontotemporal dementia and Huntington's disease. Neuropsychologia. 2003;41:688–701.Google Scholar
157.Gregory, C, Lough, S, Stone, V, et al.Theory of mind in patients with frontal variant frontotemporal dementia and Alzheimer's disease: theoretical and practical implications. Brain. 2002;125:752–764.Google Scholar
158.Lough, S, Gregory, C, Hodges, JR. Dissociation of social cognition and executive function in frontal variant frontotemporal dementia. Neurocase. 2001;7:123–130.Google Scholar
159.Hauser, MD. The liver and the moral organ. Soc Cogn Affect Neurosci. 2006;1:214–220.Google Scholar
160.Mikhail, J. Universal moral grammar: theory, evidence and the future. Trends Cogn Sci. 2007;11:143–152.Google Scholar
161.Pijnenburg, YA. The roots of social inappropriateness in frontotemporal dementia. J Neurol Neurosurg Psychiatry. 2007;78:441.Google Scholar
162.Moll, J, De Oliveira-Souza, R, Garrido, GJ, et al.The self as a moral agent: linking the neural bases of social agency and moral sensitivity. Soc Neurosci. 2007;2:336–352.Google Scholar
163.Shallice, T. ‘Theory of mind’ and the prefrontal cortex. Brain. 2001;124:247–248.Google Scholar
164.Stone, VE, Baron-Cohen, S, Calder, A, Keane, J, Young, A. Acquired theory of mind impairments in individuals with bilateral amygdalar lesions. Neuropsychologia. 2003;41:209–220.Google Scholar
165.Stuss, DT, Gallup, GG Jr, Alexander, MP. The frontal lobes are necessary for theory of mind. Brain. 2001;124:279–286.Google Scholar
166.Tankersley, D, Stowe, CJ, Huettel, SA. Altruism is associated with an increased neural response to agency. Nat Neurosci. 2007;10:150–151.Google Scholar
167.Calarge, C, Andreasen, NC, O'Leary, DS. Visualizing how one brain understands another: a PET study of theory of mind. Am J Psychiatry. 2003;160:1954–1964.Google Scholar
168.Borum, R, Fulero, SM. Empirical research on the insanity defense and attempted reforms: evidence toward informed policy. Law Hum Behav. 1999;23:375–393.Google Scholar
169.Goodenough, OR, Prehn, K. A neuroscientific approach to normative judgment in law and justice. Philos Trans R Soc Lond B Biol Sci. 2004;359:1709–1726.Google Scholar