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Tau Protein Function in Axonal Formation

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Abstract

Tau protein is a predominantly neuronal microtubule-associated protein that is enriched in axons and is capable of promoting microtubule assembly and stabilization. In the present article we review some of the key experiments directed to obtain insights about tau protein function in developing neurons. Aspects related to whether or not tau has essential, unique, or complementary functions during axonal formation are discussed.

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Authors and Affiliations

  1. Instituto Investigacion Medica Mercedes y Martin Ferreyra (IN-IMEC-CONICET), Argentina

    Gabriela Paglini & Leticia Peris

  2. Departamento Quimica Biologica (CIQUIBIC-CONICET), 5000, Cordoba, Argentina

    Faustino Mascotti & Santiago Quiroga

  3. Instituto Investigacion Medica Mercedes y Martin Ferreyra (IN-IMEC-CONICET), Argentina

    Alfredo Caceres

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  1. Gabriela Paglini
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  2. Leticia Peris
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  4. Santiago Quiroga
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  5. Alfredo Caceres
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Paglini, G., Peris, L., Mascotti, F. et al. Tau Protein Function in Axonal Formation. Neurochem Res 25, 37–42 (2000). https://doi.org/10.1023/A:1007531230651

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