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Control of Normal Mammary Epithelial Phenotype by Integrins

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Abstract

Mammary epithelial cells contact a specializedextracellular matrix in vivo known as the basementmembrane. Interactions with extracellular matrix aremediated through integrins. These cell surface receptors are involved with the formation of adhesioncomplexes, which link the extracellular matrix with theactin-based cytoskeleton, and are also associated withcomponents of growth factor signaling pathways. Differentiation of breast epithelia intolactational cells requires appropriate hormones andintegrin-mediated interactions with basement membrane.Integrins may regulate the ability of lactogenichormones to trigger their intracellular signalingpathways.

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  1. Charles H. Streuli
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  2. Gwynneth M. Edwards
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Streuli, C.H., Edwards, G.M. Control of Normal Mammary Epithelial Phenotype by Integrins. J Mammary Gland Biol Neoplasia 3, 151–163 (1998). https://doi.org/10.1023/A:1018742822565

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