REFERENCES
Abdelgadir, S. E., Resko, J. A., Ojeda, S. R., Lephart, E. D., McPaul, M. J., and Roselli, C. E. (1994). Androgens regulate aromatase cytochrome p450 messenger ribonucleic acid in rat brain. Endrocrinology 135:395–401.
Abe-Dohmae, S., Tanaka, R., and Harada, N. (1994). Cell type-and region-specific expression of aromatase mRNA in cultured brain cells. Mol. Brain Res. 24:153–158.
Adkins, E. K. (1975). Hormonal basis of sexual differentiation in the Japanese quail. J. Comp. Physiol. Psychol. 89:61–71.
Arnold, A. P. (1992). Developmental plasticity in neural circuits controlling bird song: Sexual differentiation and the neural basis of learning. J. Neurobiol. 23:1506–1528.
Arnold, A. P., and Breedlove, S. M. (1985). Organizational and activational effects of sex steroids on brain and behavior: A reanalysis. Horm. Behav. 19:469–498.
Arnold, A. P., and Gorski, R. A. (1984). Gonadal steroid induction of structural sex differences in the central nervous system. Annu. Rev. Neurosci. 7:413–442.
Arnold, A. P., Amur-Vmarjec, S., Campagnoni, A., and Schlinger, B. A. (1992). Glia express high levels of aromatase in cultures of developing zebra finch telencephalon. Soc. Neurosci. Abstr. 231.
Balthazart, J., and Foidart, A. (1993). Brain aromatase and the control of male sexual behavior. J. Steroid Biochem. Mol. Biol. 44:521–540.
Balthazart, J., Foidart, A., and Harada, N. (1990). Immunocytochemical localization of aromatase in the brain. Brain Res. 514:327–333.
Baum, M. J., Carroll, R. S., Cherry, J. A., and Tobet, S. A. (1990). Steroidal control of behavioural, neuroendocrine and brain sexual differentiation: Studies in a carnivore, the ferret. J. Neuroendocrinol. 2:401–418.
Beach, F. A. (1971). Hormonal factors controlling the differentiation, development and the display of copulatory behavior in the Ramstergig and related species. In Aronson, L., and Tobach, E. (eds.), Biopsychology of Development, Academic Press, New York, pp. 249–296.
Beyer, C., Epp, B., Fassberg, J., Reisert, I., and Pilgrim, C. (1990). Region-and sex-specific differences in maturation of astrocytes in dissociated cell cultures of embryonic rat brain. Glia 3:55–64.
Beyer, C., Pilgrim, C., and Reisert, I. (1991). Dopamine content and metabolism in mesencephalic and diencephalic cell cultures: Sex differences and effects of sex steroids. J. Neurosci. 11:1325–1333.
Beyer, C., Kolbinger, W., Froehlich, U., Pilgrim, C., and Reisert, I. (1992a). Sex differences of hypothalamic prolactin cells develop independently of the presence of sex steroids. Brain Res. 593:253–256.
Beyer, C., Eusterschulte, B., Pilgrim, C., and Reisert, I. (1992b). Sex steroids do not alter sex differences in tyrosine hydroxylase activity of dopaminergic neurons in vitro. Cell Tissue Res. 270:547–552.
Beyer, C., de la Silva, C., and Hutchison, J. B. (1993a). Kainic acid has cell-specific effects on survival of hypothalamic mouse neurones in vitro. NeuroReport 4:547–550.
Beyer, C., Wozniak, A., and Hutchison, J. B. (1993b). Sex-specific aromatization of testosterone in mouse hypothalamic neurons. Neuroendocrinology 58:673–681.
Beyer, C., Green, S. J., and Hutchison, J. B. (1994a). Androgens influence sexual differentiation of embryonic mouse hypothalamic aromatase neurons in vitro. Endocrinology 135:1220–1226.
Beyer, C., Green, S. J., Barker, P. J., Huskisson, N. S., and Hutchison, J. B. (1994b). Aromatase-immunoreactivity is localised specifically in neurones in the developing mouse hypothalamus and cortex. Brain Res. 638:203–210.
Breedlove, S. M. (1992). Sexual dimorphism in the vertebrate nervous system. J. Neurosci. 12:4133–4142.
Breedlove, S. M., and Arnold, A. P. (1983). Hormonal control of a developing neuromuscular system. II. Sensitive periods for the androgen-induced masculinization of the rat spinal nucleus of the bulbocavernosus. J. Neurosci. 3:424–432.
Callard, G. V., and Pasmanik, M. (1987). The role of estrogen as a parahormone in brain and pituitary. Steroids 50:475–493.
Callard, G. V., Drygas, M., and Gelinas, D. (1993). Molecular and cellular physiology of aromatase in the brain and retina. J. Steroid Biochem. Mol. Biol. 44:541–547.
Canick, J. A., Tobet, S. A., Baum, M. J., Vaccaro, D. E., Ryan, K. J., Leeman, S. E., and Fox, T. O. (1987). Studies on the role of catecholamines in the regulation of the developmental pattern of the hypothalamic aromatase. Steroids 50:509–521.
Choate, J. V. A., and Resko, J. A. (1994). Prenatal inhibition of aromatase activity effects luteinizing hormone feedback mechanisms and reproductive behaviors of adult guinea pigs. Biol. Reprod. 51:1273–1278.
Connolly, P. B., Roselli, C. E., and Resko, J. A. (1994). Aromatase activity in developing guinea pig brain: Ontogeny and effects of exogenous androgens. Biol. Reprod. 50:436–441.
Ehret, G. (1987). Left hemisphere advantage in the mouse brain for recognizing ultrasonic communication calls. Nature 325:249–251.
Gahr, M., and Hutchison, J. B. (1992). Behavioral action of estrogen in the male dove brain: Area differences in codistribution of aromatase activity and estrogen receptors are steroid-dependent. Neuroendocrinology 56:74–84.
Garcia-Seguar, L. M., Baetens, D., and Naftolin, F. (1986). Synaptic remodelling in arcuate nucleus after injection of estradiol valerate in adult female rats. Brain Res. 366:131–136.
Garcia-Segura, L. M., Olmos, G., Tranque, P., and Naftolin, F. (1987). Rapid effects of gonadal steroids upon hypothalamic neuronal membrane ultrastructure. J. Steroid Biochem. 27:615–623.
George, F. W., and Ojeda, S. R. (1982). Changes in aromatase activity in the rat brain during embryonic, neonatal and infantile development. Endocrinology 111:522–529.
Gorski, R. A., Gordon, J. H., Shryme, J. E., and Southam, A. M. (1978). Evidence for a morphological sex difference within the medial preoptic area of the rat brain. Brain Res. 148:333–346.
Gould, E., and McEwen, B. S. (1993). Neuronal birth and death. Curr. Opin. Neurobiol. 3:676–682.
Gould, E., Woolley, C. S., Frankfurt, M., and McEwen, B. S. (1990). Gonadal steroids regulate dendritic spine density in hippocampal pyramidal cells in adulthood. J. Neurosci. 10:1286–1291.
Goy, R. W., and McEwen, B. S. (1980). Sexual Differentiation of the Brain, MIT Press, Cambridge, MA.
Harada, N. (1988). Novel properties of human placental aromatase as cytochrome P-450: Purification and characterization of a unique form of aromatase. J. Biochem. 103:106–113.
Harada, N., and Yamada, K. (1992). Ontogeny of aromatase messenger ribonucleic acid in mouse brain: Fluorometrical quantitation by polymerase chain reaction. Endocrinology 131:2306–2312.
Harada, N., Abe-Dohmae, S., Loeffen, R., Foidart, A., and Balthazart, J. (1993). Synergism between androgens and estrogens in the induction of aromatase and its messenger RNA in the brain. Brain Res. 622:243–256.
Harris, G. W., and Levine, S. (1965). Sexual differentiation of the brain and its experimental control. J. Physiol. 181:379–400.
Holman, S. D., and Hutchison, J. B. (1991). Differential effects of neonatal castration on the development of sexually dimorphic brain areas in the gerbil. Dev. Brain Res. 61:147–150.
Hutchison, J. B. (1978). Hypothalamic regulation of male sexual responsiveness to androgen. In Hutchison, J. B. (ed.), Biological Determinants of Sexual Behaviour, John Wiley & Sons, Chichester, pp. 277–319.
Hutchison, J. B. (1991). How does the environment influence the behavioural action of hormones? In Bateson, P. P. G. (ed), The Development and Integration of Behaviour, Cambridge University Press, Cambridge, pp. 149–170.
Hutchison, J. B., and Hutchison, R. E. (1985). Phasic effects of hormones in the avian brain during behavioural development. In Giles, R., and Bathazart, J. (eds.), Neurobiology, Springer-Verlag, Berlin, pp. 105–120.
Hutchison, J. B., and Hutchison, R. E. (1990). Sexual development at the neurohormonal level: The role of androgens. In Feierman, J. (ed.), Pedophilia: Biosocial Dimensions, Springer Verlag, Berlin, pp. 510–543.
Hutchison, J. B., and Steimer, Th. (1984). Androgen metabolism in the brain: Behavioural correlates. Prog. Brain Res. 61:23–51.
Hutchison, J. B., Wingfield, J. C., and Hutchison, R. E. (1984). Sex differences in plasma concentrations of steroids during the sensitive period for brain differentiation in the zebra finch. J. Endocrinol. 103:363–369.
Hutchison, R. E., Hutchison, J. B., Steimer, Th., Steel, E., Powers, J. B., Walker, A. P., Herbert, J., and Hastings, M. H. (1991). Brain aromatization of testosterone in the male Syrian hamster: Effects of androgen and photoperiod. Neuroendocrinology 53:194–203.
Hutchison, J. B., Beyer, C., Green, S., and Wozniak, A. (1994). Brain formation of oestrogen in the mouse. Sex dimorphism in aromatase development. J. Steroid Biochem. Mol. Biol. 49:407–415.
Hutchison, J. B., Wozniak, A., Beyer, C., and Hutchison, R. E. (1996). Regulation of sex-specific formation of oestrogen in brain development: Endogenous inhibitors of aromatase. J. Steroid Biochem. Mol. Biol. 56:201–207.
Hutchison, R. E. (1978). Hormonal differentiation of sexual behaviour in Japanese quail. Horm. Behav. 11:363–387.
Jost, A. A. (1972). A new look at the mechanisms controlling sex differentiation in mammals. John Hopkins Med. J. 130:38–53.
Jost, A. A., and Magre, S. (1984). Testicular development phases and dual hormonal control of sexual organogenesis. In Serio, M., Motta, M., Aznisi, M., and Martini, L. (eds.), Sexual Differentiation: Basic and Clinical Aspects, Raven Press, New York, pp. 1–15.
Kawata, M. (1995). Roles of steroid hormones and their receptors in structural organization in the nervous system. Neurosci. Res. 24:1–46.
Kolbinger, W., Trepel, M., Beyer, C., Pilgrim, Ch., and Reisert, I. (1991). The influence of genetic sex on sexual differentiation of diencephalic dopaminergic neurons in vitro and in vivo. Brain Res. 544:349–352.
Komisaruk, B. R., Adler, N. T., and Hutchison, J. B. (1972). Genital sensory field: Enlargement by oestrogen treatment in female rats. Science 178:1295–1298.
Konishi, M. (1989). Birdsong for neurobiologists. Neuron 3:541–549.
Konishi, M., and Akutagawa, E. (1990). Growth and atrophy of neurons labeled at their birth in a song nucleus of the zebra finch. Proc. Natl. Acad. Sci. USA 87:3538–3541.
Krohmer, R. W., and Baum, M. J. (1989). Effect of sex, intrauterine position and androgen manipulation on the development of brain aromatase activity in fetal ferrets. J. Neuroendocrinol. 1:265–271.
Lauber, M. E., and Lichtensteiger, W. (1994). Pre-and postnatal ontogeny of aromatase cytochrome p450 messenger ribonucleic acid expression in the male rat brain studied by in situ hybridization. Endocrinology 135:1661–1668.
Lephart, E. D., and Ojeda, S. R. (1990). Hypothalamic aromatase activity in male and female rats during juvenile peripubertal development. Neuroendocrinology 51:385–393.
Lephart, E. D., Simpson, E. R., and Ojeda, S. R. (1991). Effects of cyclic AMP and androgens on in vitro brain aromatase enzyme activity during prenatal development in the rat. J. Neuroendocrinol. 4:29–35.
MacLusky, N. J., and Naftolin, F. (1981). Sexual differentiation of the central nervous system. Science 211:1294–1303.
MacLusky, N. J., Philip, A., Hurlburt, C., and Naftolin, F. (1985). Estrogen formation in the developing rat brain: Sex differences in aromatase activity during early post-natal life. Psychoneuroendocrinology 10:355–361.
MacLusky, N. J., Clark, A. S., Naftolin, F., and Goldman-Rakic, P. S. (1987). Estrogen formation in the mammalian brain: Possible role of aromatase in sexual differentiation of the hippocampus and neocortex. Steroids 50:459–474.
Matsumoto, A. (1991). Synaptogenic action of sex steroids in developing and adult neuroendocrine brain. Psychoneuroendocrinology 16:25–40.
McEwen, B. S., Lieberburg, I., Chaptal, C., and Krey, L. (1979). Aromatization: Important for sexual differentiation of the neonatal rat brain. Horm. Behav. 9:249–263.
McPhaul, M. J., Noble, J. F., Simpson, E. R., Mendelson, C. R., and Wilson, J. D. (1988). The expression of a functional cDNA encoding the chicken cytochrome P-450arom (aromatase) that catalyses the formation of estrogen from androgen. J. Biol. Chem. 263:16358–16363.
Melcangi, R. C., Celotti, F., Castano, P., and Martini, L. (1993). Differential localization of the 5-alpha-reductase and the 3-alpha-hydroxysteroid dehydrogenase in neuronal and glial cultures. Endocrinology 132:1252–1259.
Naftolin, F. (1994). Brain aromatization of androgens. J. Reprod. Med. 39:257–261.
Naftolin, F., Ryan, K. J., Davies, I. J., Reddy, V. V., Flores, F., Petro, Z., Kuhn, M., White, R. J., Takaoka, Y., and Wolin, L. (1975). Formation of estrogens by central neuroendocrine tissues. Rec. Prog. Horm. Res. 31:295–319.
Naftolin, F., Garcia-Segura, L. M., Keefe, D., Leranth, C., MacLusky, N. J., and Brawer, J. R. (1990). Estrogen effects on the synaptology and neural membranes of the rat hypothalamic arcuate nucleus. Biol. Reprod. 42:21–28.
Nishizuka, M., and Arai, Y. (1981). Organizational action of estrogen on synaptic pattern in the amygdala: Implications for sexual differentiation of the brain. Brain Res. 213:422–426.
Nottebohm, F. (1980). Testosterone triggers growth of brain vocal control nuclei in adult female canaries. Brain Res. 189:429–436.
Nottebohm, F., and Arnold, A. (1976). Sexual dimorphism in vocal control areas of the songbird brain. Science 194:211–213.
Nottebohm, F., Alvarez-Buylla, A., Cynx, J., Kim, J., Ling, C-.Y., Nottebohm, M., Sutter, R., Tolles, A., and Williams, H. (1990). Song learning in birds: The relationship between perception and production. In Krebs, J. R., and Horn, G. (eds.), Philosophical Transactions: Biological Sciences, Vol. 329, Royal Society of London, London, pp. 115–124.
Nottebohm, F. (1980). Testosterone triggers growth of brain vocal control nuclei in adult female canaries. Brain Res. 189:429–436.
Nottebohm, F., and Arnold, A. (1976). Sexual dimorphism in vocal control areas of the songbird brain. Science 194:211–213.
Olsen, K. L. (1985). Genetic determinants of sexual differentiation. In Balthazart, J., Pröve, E., and Gilles, R. (eds.), Hormones and Behaviour in Higher Vertebrates, Springer-Verlag, Berlin, pp. 138–158.
Phoenix, Ch. H., Goy, R. W., Gerall, A. A., and Young, W. C. (1959). Organizing action of prenatally administered testerone propionate on the tissues mediating mating behavior in the female guinea pig. Endocrinology 55:369–382.
Pilgrim, C., and Hutchison, J. B. (1994). Developmental regulation of sex differences in the brain: Can the role of gonadal steroids be re-defined? Neuroscience 60:843–855.
Pons, S., and Torres-Aleman, I. (1993). Estradiol modulates insulin-like growth factor I receptors and binding proteins in neurons from the hypothalamus. J. Neuroendocrinol. 5:267–271.
Roselli, C. E., Elinwood, W. E., and Resko, J. A. (1984). Regulation of brain aromatase activity in rats. Endocrinology 14:192–200.
Sanghera, M. K., Simpson, E. R., McPhaul, M. J., Kozlowski, G., Conley, A. J., and Lephart, E. D. (1991). Immunocytochemical distribution of aromatase cytochrome P450 in the rat brain using peptide-generated polyclonal antibodies. Endocrinology 129:2834–2844.
Schlinger, B. A. (1994). Estrogens to song: Picograms to sonograms. Horm. behav. 28:191–198.
Schlinger, B. A., and Arnold, A. P. (1991). Brain is the major site of estrogen synthesis in a male songbird. Proc. Natl. Acad. Sci. USA 88:4191–4194.
Schlinger, B. A., Amur-Umarjee, S., Shen, P., Campagnoni, A. T., and Arnold, A. P. (1994). Neuronal and non-neuronal aromatase in primary cultures of developing zebra finch telencephalon. J. Neurosci. 14:7541–7552.
Schumacher, M., and Balthazart, J. (1985). Sexual differentiation is a biphasic process in mammals and birds. In Gilles, R., and Balthazart, J. (eds.), Neurobiology, Springer-Verlag, Berlin, pp. 203–219.
Schumacher, M., and Balthazart, J. (1986). Testosterone-induced brain aromatase is sexually dimorphic. Brain Res. 370:285–293.
Schumacher, M., and Hutchison, J. B. (1986). Testosterone induces hypothalamic aromatase during early development in quail. Brain Res. 377:63–72.
Schumacher, M., Hutchison, R. E., and Hutchison, J. B. (1988). Ontogeny of testosterone-inducible brain aromatase activity. Brain Res. 441:98–110.
Simpson, E. R. (1991). Regulation of expression of the genes encoding steroidogenic enzymes. J. Steroid Biochem. Mol. Biol. 40:45–52.
Steimer, Th., and Hutchison, J. B. (1981). Androgen increases formation of behaviourally effective oestrogen in the dove brain. Nature 292:345–347.
Steimer, Th., and Hutchison, J. B. (1990). Is androgen-dependent aromatase activity sexually differentiated in the rat and dove preoptic area? J. Neurobiol. 21:787–795.
Terashima, M., Toda, K., Kawamoto, T., Kuribayashi, I., Ogawa, Y., Maeda, t., and Shizuta, Y. (1991). Isolation of a full-length cDNA encoding mouse aromatase p450. Arch. Biochem. Biophys. 285:231–237.
Tobet, S. A., Baum, M. J., Tang, H. B., Shim, J. S., and Canick, J. A. (1985). Aromatase activity in the perinatal rat forebrain: Effects of age, sex and intra-uterine position. Dev. Brain Res. 23:171–178.
Tsuruo, Y., Ishimura, K., Fujita, H., and Osawa, Y. (1994). Immunocytochemical localization of aromatase-containing neurons in the rat brain during pre-and postnatal development. Cell Tissue Res. 278:29–39.
Tsuruo, Y., Ishimura, K., and Osawa, Y. (1995). Presence of estrogen-receptors in aromatase-immunoreactive neurons in the mouse-brain. Neurosci. Lett. 195:49–52.
Tsuruo, Y., Ishimura, K., Hayashi, S., and Osawa, Y. (1996). Immunohistochemical localization of estrogen-receptors within aromatase-immunoreactive neurons in the fetal and neonatal rat-brain. Anat. Embryol. 193:115–121.
Tsutui, K., and Yamazaki, T. (1995). Avian neurosteroids. I. Pregnenolone biosynthesis in the quail brain. Brain Res. 678:1–9.
Usui, M., Yamazaki, T., Kominami, S., and Tsutsui, K. (1995). Avian neurosteroids. II. Localization of a cytochrome p450scc-like substance in the quail brain. Brain Res. 678:10–20.
von Ziegler, N. I., and Lichtensteiger, W. (1992). Asymmetry of brain aromatase activity: Region-and sex-specific developmental patterns. Neuroendocrinology 55:512–518.
Weaver, C. E., and Baum, M. J. (1991). Differential regulation of brain aromatase by androgen in adult and fetal ferrets. Endocrinology 128:1247–1254.
Weisz, J., Brown, B. L., and Ward, I. L. (1982). Maternal stress decreases steroid aromatase activity in brains of male and female rat fetuses. Neuroendocrinology 35:374–379.
Whalen, R. E. (1974). Sexual differentiation: Models, methods and mechanisms. In Friedman, R. C., Richart, R. M., and van de Wiele, R. L. (eds.), Sex Differences in behavior, Wiley, New York, p. 467.
Wozniak, A., Hutchison, R. E., and Hutchison, J. B. (1992). Localisation of aromatase activity in androgen target areas of the mouse brain. Neurosci. Lett. 146:191–194.
Yahr, P. (1985). Searching for the neural correlates of sexual differentiation in a heterogeneous tissue. In Gilles, R., and Balthazart, J. (eds.), Neurobiology, Springer-Verlag, Berlin, pp. 180–203.
Yahr, P. (1988). Sexual differentiation of behavior in the context of developmental psychology. In Blass, E. M. (ed.), Handbook of Behavioral Neurobiology, 9, Plenum Press, New York, pp. 197–243.
Yahr, P., and Stevens, D. R. (1987). Hormonal control of sexual and scent marking behaviors of male gerbils in relation to the sexually dimorphic area of the hypothalamus. Horm. Behav. 21:331–346.
Yamada, K., Harada, N., Tamaru, M., and Takagi, Y. (1993). Effects of changes in gonadal hormones on the amount of aromatase messenger RNA in mouse brain diencephalon. Biochem. Biophys. Res. Commun. 195:462–468.
Yamada, N. M., Hirata, S., and Kato, J. (1994). Distribution and postnatal changes of aromatase mRNA in the female rat brain. J. Steroid Biochem. Mol. Biol. 48:529–533.
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Hutchison, J.B. Gender-Specific Steroid Metabolism in Neural Differentiation. Cell Mol Neurobiol 17, 603–626 (1997). https://doi.org/10.1023/A:1022581902880
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DOI: https://doi.org/10.1023/A:1022581902880