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No Difference in Hippocampus Volume Detected on Magnetic Resonance Imaging in Autistic Individuals

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Abstract

Neuropathological and animal studies have implicated the hippocampus as having a potential role in autism. Current imaging methods are well suited to the detailed measurement of the volume of the hippocampus, which has received little attention in previous imaging studies in autism. We report the results of a magnetic resonance imaging (MRI) study of 35 autistic and 36 control subjects. Detailed (1.5 mm) MRI did not reveal differences in the volume of the hippocampus in autistic individuals.

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REFERENCES

  • American Psychiatric Association. (1987). Diagnostic and statistical manual of mental disorders (3rd ed., Rev.). Washington, DC: Author.

    Google Scholar 

  • Andreasen, N. C., Rajaprabhakaran, R., & Cizadlo, T. (1994). Automatic atlas-based dissection of human brain from MR images. San Francisco: Society of Magnetic Resonance in Medicine.

    Google Scholar 

  • Andreasen, N. C., Cohen, G., Harris, G., Cizadlo, T., Parkkinen, J., Rezai, K., & Swayze, V. (1992). Image processing for the study of brain structure and function: Problems and programs. Journal of Neuropsychiatry and Clinical Neuroscience, 4, 125–133.

    Google Scholar 

  • Andreasen, N. C., Harris, G., Cizadlo, T., Arndt, S., O'Leary, D. S., Swayze, V. W., & Flaum, M. (1994). Techniques for measuring sulcal/gyral patterns in the brain as visualized through MR scanning: BRAINPLOT and BRAINMAP. Proceedings of the National Academy of Sciences of the United States of America, 900, 93–97.

    Google Scholar 

  • Andreasen, N. C., Rajaprabhakaran, R., Cizadlo, T., Arndt, S., Swayze, V. W., II, Flashman, L. A., O'Leary, D. S., Ehrhardt, J. C., & Yuh, W. C. (1996). Automatic atlas-based volume estimation of human brain regions from MR images. Journal of Computer Assisted Tomography 20, 98–106.

    Google Scholar 

  • Arndt, S., Swayze, V., Cizadlo, T., O'Leary, D., Cohen, G., Yuh, W. T. C., Ehrhardt, J., & Andreasen, N. C. (1994). Evaluating and validating two methods for estimating brain structure volumes: Tessellation and simple pixel counting. Neuroimage, 1, 191–198.

    Google Scholar 

  • Arndt, S., Rajarethinam, R., Cizadlo, T, O'Leary, D. S., Downhill, J., & Andreasen, N. C. (1996). Landmark-based MR Image Registration and Measurement: A Reliability Study. Psychiatric Research—Neuroimaging, 67, 145–154.

    Google Scholar 

  • Arthur, G. (1952). The Arthur Adaptation of the Leiter International Performance Scale. Chicago: Psychological Service Center Press.

    Google Scholar 

  • Bachevalier, J., & Merjanian, P. M. (1994). The contribution of medial temporal lobe structures in infantile autism: A neurobehavioral study in primates. In M. L. Bauman & T. L. Kemper (Eds.), The neurobiology of autism (pp. 146–169). Baltimore: Johns Hopkins University Press.

    Google Scholar 

  • Bauman, M. L., & Kemper, T. L. (1994). Neuroanatomic observations of the brain in autism. In M. L. Bauman & T. L. Kemper (Eds.), The neurobiology of autism. Baltimore: Johns Hopkins University Press.

    Google Scholar 

  • Cizadlo, T., Andreasen, N. C., Zeien, G., Rajaprabhakaran, R., Harris, G., O'Leary, D. S., Swayze, V. W., Arndt, S., Hichwa, R., Ehrhardt, J., & Yuh, W. T. C. (1994). Image registration issues in the analysis of multiple-injection 150H20 PET studies: BRAINFIT. Society Photo-Optical Instrumentation Engineers, International Society for Optical Engineering, 2168, 423–430.

    Google Scholar 

  • Cohen, G., Andreasen, N. C., Alliger, R., Arndt, S., Kaun, J., Yuh, W. T. C., & Ehrhardt, J. (1992). Segmentation techniques for the classification of brain tissue using magnetic resonance imaging. Psychiatry Research: Neuroimaging, 46, 33–51.

    Google Scholar 

  • DeLong, R. G. (1992). Autism, amnesia, hippocampus, and learning. Neuroscience & Behavioral Reviews, 16, 63–70.

    Google Scholar 

  • Filipek, P. A., Richelme, C., Kennedy, C. N., Rademacher, J., Pitcher, D. A., Zidel, S., & Caviness, V. S. (1992). Morphometric analysis of the brain in developmental language disorder and autism. Annals of Neurology, 32, 475. (abstract).

    Google Scholar 

  • Lainhart, J. E., & Piven, J. (1995). Diagnosis, treatment, and neurobiology of autism in children. Current Opinion in Pediatrics, 4, 392–400.

    Google Scholar 

  • Le Couteur, A., Rutter, M., Lord, C., Rios, P., Holdgrafer, M., and McLennan, J. (1989). Autism Diagnostic Interview: A standardized investigator-based instrument. Journal of Autism and Developmental Disorders, 19, 363–386.

    Google Scholar 

  • Piven, J., Arndt, S., Bailey, J., & Andreasen, N. (1996). Regional brain enlargement in autism: A magnetic resonance imaging study. Journal of the American Academy of Child & Adolescent Psychiatry, 35, 530–536.

    Google Scholar 

  • Piven, J., Nehme, E., Simon, J., Barta, P., Pearlson, G., & Folstein, S. F. (1992). Magnetic resonance imaging in autism: Measurement of the cerebellum, pons, and fourth ventricle. Biological Psychiatry, 31, 491–504.

    Google Scholar 

  • Rauch, R. A., & Jinkins, J. R. (1996). Variability of corpus callosal area measurements from midsagittal MR images: Effect of subject placement within the scanner. American Journal of Neuroradiology, 17, 27–28.

    Google Scholar 

  • Saitoh, O., Courchesne, E., Egaas, B., Lincoln, A. J., & Schreibman, L. (1995). Cross-sectional area of the posterior hippocampus in autistic patients with cerebellar and corpus callosum abnormalities. Neurology, 45, 317–324.

    Google Scholar 

  • Watson, C., Andermann, F., Gloor, P., Jones-Gotman, M., Peters, T., Evans, A., Olivier, A., Melanson, D., & Leroux, G. (1992). Anatomic basis of amygdaloid and hippocampal volume measurement by magnetic resonance imaging. Neurology, 42, 1743–1750.

    Google Scholar 

  • Wechsler, D. (1981). Wechsler Adult Intelligence Scale (Rev.). San Antonio, TX: Psychological Corp.

    Google Scholar 

  • Wechsler, D. (1991). Wechsler Intelligence Scale for Children (3rd ed.). San Antonio, TX: Psychological Corporation.

    Google Scholar 

  • World Health Organization. (1993). The ICD-10 classification of mental and behavioral disorders. Diagnostic criteria for research. Geneva: Author.

    Google Scholar 

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Piven, J., Bailey, J., Ranson, B.J. et al. No Difference in Hippocampus Volume Detected on Magnetic Resonance Imaging in Autistic Individuals. J Autism Dev Disord 28, 105–110 (1998). https://doi.org/10.1023/A:1026084430649

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  • DOI: https://doi.org/10.1023/A:1026084430649

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