Abstract
Neuropathological and animal studies have implicated the hippocampus as having a potential role in autism. Current imaging methods are well suited to the detailed measurement of the volume of the hippocampus, which has received little attention in previous imaging studies in autism. We report the results of a magnetic resonance imaging (MRI) study of 35 autistic and 36 control subjects. Detailed (1.5 mm) MRI did not reveal differences in the volume of the hippocampus in autistic individuals.
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REFERENCES
American Psychiatric Association. (1987). Diagnostic and statistical manual of mental disorders (3rd ed., Rev.). Washington, DC: Author.
Andreasen, N. C., Rajaprabhakaran, R., & Cizadlo, T. (1994). Automatic atlas-based dissection of human brain from MR images. San Francisco: Society of Magnetic Resonance in Medicine.
Andreasen, N. C., Cohen, G., Harris, G., Cizadlo, T., Parkkinen, J., Rezai, K., & Swayze, V. (1992). Image processing for the study of brain structure and function: Problems and programs. Journal of Neuropsychiatry and Clinical Neuroscience, 4, 125–133.
Andreasen, N. C., Harris, G., Cizadlo, T., Arndt, S., O'Leary, D. S., Swayze, V. W., & Flaum, M. (1994). Techniques for measuring sulcal/gyral patterns in the brain as visualized through MR scanning: BRAINPLOT and BRAINMAP. Proceedings of the National Academy of Sciences of the United States of America, 900, 93–97.
Andreasen, N. C., Rajaprabhakaran, R., Cizadlo, T., Arndt, S., Swayze, V. W., II, Flashman, L. A., O'Leary, D. S., Ehrhardt, J. C., & Yuh, W. C. (1996). Automatic atlas-based volume estimation of human brain regions from MR images. Journal of Computer Assisted Tomography 20, 98–106.
Arndt, S., Swayze, V., Cizadlo, T., O'Leary, D., Cohen, G., Yuh, W. T. C., Ehrhardt, J., & Andreasen, N. C. (1994). Evaluating and validating two methods for estimating brain structure volumes: Tessellation and simple pixel counting. Neuroimage, 1, 191–198.
Arndt, S., Rajarethinam, R., Cizadlo, T, O'Leary, D. S., Downhill, J., & Andreasen, N. C. (1996). Landmark-based MR Image Registration and Measurement: A Reliability Study. Psychiatric Research—Neuroimaging, 67, 145–154.
Arthur, G. (1952). The Arthur Adaptation of the Leiter International Performance Scale. Chicago: Psychological Service Center Press.
Bachevalier, J., & Merjanian, P. M. (1994). The contribution of medial temporal lobe structures in infantile autism: A neurobehavioral study in primates. In M. L. Bauman & T. L. Kemper (Eds.), The neurobiology of autism (pp. 146–169). Baltimore: Johns Hopkins University Press.
Bauman, M. L., & Kemper, T. L. (1994). Neuroanatomic observations of the brain in autism. In M. L. Bauman & T. L. Kemper (Eds.), The neurobiology of autism. Baltimore: Johns Hopkins University Press.
Cizadlo, T., Andreasen, N. C., Zeien, G., Rajaprabhakaran, R., Harris, G., O'Leary, D. S., Swayze, V. W., Arndt, S., Hichwa, R., Ehrhardt, J., & Yuh, W. T. C. (1994). Image registration issues in the analysis of multiple-injection 150H20 PET studies: BRAINFIT. Society Photo-Optical Instrumentation Engineers, International Society for Optical Engineering, 2168, 423–430.
Cohen, G., Andreasen, N. C., Alliger, R., Arndt, S., Kaun, J., Yuh, W. T. C., & Ehrhardt, J. (1992). Segmentation techniques for the classification of brain tissue using magnetic resonance imaging. Psychiatry Research: Neuroimaging, 46, 33–51.
DeLong, R. G. (1992). Autism, amnesia, hippocampus, and learning. Neuroscience & Behavioral Reviews, 16, 63–70.
Filipek, P. A., Richelme, C., Kennedy, C. N., Rademacher, J., Pitcher, D. A., Zidel, S., & Caviness, V. S. (1992). Morphometric analysis of the brain in developmental language disorder and autism. Annals of Neurology, 32, 475. (abstract).
Lainhart, J. E., & Piven, J. (1995). Diagnosis, treatment, and neurobiology of autism in children. Current Opinion in Pediatrics, 4, 392–400.
Le Couteur, A., Rutter, M., Lord, C., Rios, P., Holdgrafer, M., and McLennan, J. (1989). Autism Diagnostic Interview: A standardized investigator-based instrument. Journal of Autism and Developmental Disorders, 19, 363–386.
Piven, J., Arndt, S., Bailey, J., & Andreasen, N. (1996). Regional brain enlargement in autism: A magnetic resonance imaging study. Journal of the American Academy of Child & Adolescent Psychiatry, 35, 530–536.
Piven, J., Nehme, E., Simon, J., Barta, P., Pearlson, G., & Folstein, S. F. (1992). Magnetic resonance imaging in autism: Measurement of the cerebellum, pons, and fourth ventricle. Biological Psychiatry, 31, 491–504.
Rauch, R. A., & Jinkins, J. R. (1996). Variability of corpus callosal area measurements from midsagittal MR images: Effect of subject placement within the scanner. American Journal of Neuroradiology, 17, 27–28.
Saitoh, O., Courchesne, E., Egaas, B., Lincoln, A. J., & Schreibman, L. (1995). Cross-sectional area of the posterior hippocampus in autistic patients with cerebellar and corpus callosum abnormalities. Neurology, 45, 317–324.
Watson, C., Andermann, F., Gloor, P., Jones-Gotman, M., Peters, T., Evans, A., Olivier, A., Melanson, D., & Leroux, G. (1992). Anatomic basis of amygdaloid and hippocampal volume measurement by magnetic resonance imaging. Neurology, 42, 1743–1750.
Wechsler, D. (1981). Wechsler Adult Intelligence Scale (Rev.). San Antonio, TX: Psychological Corp.
Wechsler, D. (1991). Wechsler Intelligence Scale for Children (3rd ed.). San Antonio, TX: Psychological Corporation.
World Health Organization. (1993). The ICD-10 classification of mental and behavioral disorders. Diagnostic criteria for research. Geneva: Author.
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Piven, J., Bailey, J., Ranson, B.J. et al. No Difference in Hippocampus Volume Detected on Magnetic Resonance Imaging in Autistic Individuals. J Autism Dev Disord 28, 105–110 (1998). https://doi.org/10.1023/A:1026084430649
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DOI: https://doi.org/10.1023/A:1026084430649