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Structure, function and pathology of O-mannosyl glycans

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Abstract

Animal cells contain many glycoproteins, i.e., proteins with covalently liked sugar chains. The major glycans of glycoproteins can be classified into two groups, N-glycans and O-glycans, according to their glycan-peptide linkage regions. Development of sensitive methods for the analyses of glycan structures have revealed a new type of glycosidic linkage to the peptide portion, the O-mannosyl linkage, in mammals, which used to be considered specific to yeast. O-Mannosylation is present in a limited number of glycoproteins of brain, nerve, and skeletal muscle. Recently O-mannosylation has been shown to be important in muscle and brain development. Glycobiology of O-mannosyl glycans is expected to produce remarkable advances in the understanding and treatment of congenital muscular dystrophies. In this article, I describe the structure, biosynthesis, and pathology of O-mannosyl glycans. Published in 2004.

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Authors and Affiliations

  1. Glycobiology Research Group, Tokyo Metropolitan Institute of Gerontology, Foundation for Research on Aging and Promotion of Human Welfare, 35-2 Sakaecho, Itabashi-ku, Tokyo, 173-0015, Japan

    Tamao Endo

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Endo, T. Structure, function and pathology of O-mannosyl glycans. Glycoconj J 21, 3–7 (2004). https://doi.org/10.1023/B:GLYC.0000043740.26062.2c

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