Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Interneurons and the ghost of the sea

Nature Neuroscience volume 1, pages 434–436 (1998)Cite this article

Abstract

Kainate receptor activation excites hippocampal pyramidal neurons in a model of epilepsy. Two new studies indicate that kainate acts on GABAergic interneurons to produce this effect.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Ionotropic glutamate receptor antagonists.
Figure 2: Functional localization of KA receptors (K) on inhibitory neurons and pyramidal cells of the hippocampus.

References

  1. McGeer, E. G. Olney, J. W. & McGeer, P. L. Kainic Acid as a Tool in Neurobiology (Raven Press, New York, 1978).

    Google Scholar 

  2. Ben-Ari, Y. Neurosci. 14, 375–403 (1985).

    Article  CAS  Google Scholar 

  3. Cossart, R., Esclapez, M., Hirsch, J. C., Bernard, C. & Ben-Ari, Y. Nature Neurosci. 1, 470–478, (1998).

  4. Frerking, M., Malenka, R. C. & Nicoll, R. A. Nature Neuroscience 1, 479–486, (1998).

    Article  CAS  Google Scholar 

  5. Lerma, J., Morales, M., Vicente, M. A. & Herreras, O. . Trends Neurosci. 20, 9–12 (1997).

    Article  CAS  Google Scholar 

  6. Castillo, P. E., Malenka, R. C. & Nicoll, R. A. Nature 388, 182– 186 (1997).

    Article  CAS  Google Scholar 

  7. Vignes, M. & Collingridge, G. L. Nature 388, 179–182 (1997).

    Article  CAS  Google Scholar 

  8. Mulle, C. et al. Nature 392, 601–605 (1998).

    Article  CAS  Google Scholar 

  9. Chittajallu, R. et al. Nature 379, 78– 81 (1996).

    Article  CAS  Google Scholar 

  10. Fisher, R. S. & Alger, B. E. J. Neurosci. 4, 1312–1323 (1984).

    Article  CAS  Google Scholar 

  11. Clarke, V. R. et al. Nature 389, 599–603 (1997).

    Article  CAS  Google Scholar 

  12. Rodríguez-Moreno, A., Herreras, O. & Lerma, J. Neuron 19, 893– 901 (1997).

    Article  Google Scholar 

  13. Rodriguez-Moreno, A. & Lerma, J. Neuron 20, 1211–1218 (1998).

  14. Kamiya, H. & Ozawa, S. J. Physiol. (Lond.) 509, 833–845 (1998).

    Article  CAS  Google Scholar 

  15. Freund, T. F. & Buzsáki, G. Hippocampus 6, 347–470 (1996).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurology, UCLA School of Medicine Reed Neurological Research Center, 710 Westwood Plaza, Los Angeles, 90095-1769, California, USA

    Istvan Mody

Authors
  1. Istvan Mody
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mody, I. Interneurons and the ghost of the sea. Nat Neurosci 1, 434–436 (1998). https://doi.org/10.1038/2151

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/2151

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing