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Growth of Pulmonary Alveolar Macrophages in vitro

Nature volume 245, pages 150–152 (1973)Cite this article

Abstract

THE mammalian pulmonary alveolar macrophage (PAM) plays a primary role in removing and detoxifying foreign materials reaching the terminal airways1–4. The metabolic characteristics of PAMs associated with their function as detoxifying and clearing agents in situ have been the subject of recent study5–8, but the PAM remains a poorly studied cell type9. PAMs have been considered a specialized cell type incapable of survival in vitro for extended periods or of division in culture10,11. In the lung, the PAM population is constantly being renewed12–15: cells leave the lung by migration into the blood16,17, the lymphatic system9,18, by cell breakdown and clearance by other PAMs19, or by mucociliary transport1,15,16,20; and are renewed by migration of stem cells to the lung mterstitium13,14,21, by division of precursor cells in the interstitium22,23, or by division of mature PAMs in the alveoli24.

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Authors and Affiliations

  1. Virginia Mason Research Center, Seattle, Washington, 98101

    S. C. SODERLAND & Y. NAUM

  2. Departments of Medicine and Biological Structure, University of Washington, Seattle, Washington, 98105

    S. C. SODERLAND & Y. NAUM

Authors
  1. S. C. SODERLAND
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  2. Y. NAUM
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SODERLAND, S., NAUM, Y. Growth of Pulmonary Alveolar Macrophages in vitro. Nature 245, 150–152 (1973). https://doi.org/10.1038/245150a0

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