Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Presynaptic inhibition at mammalian peripheral synapse?

Nature volume 250, pages 430–431 (1974)Cite this article

Abstract

STIMULATION of sympathetic nerves leading to the intestine causes a reduction in intestinal motility1. Norberg2 showed that these nerves ramify mainly in the enteric plexuses and has suggested that inhibition may be exerted at a neural rather than at a muscular level but this suggestion has been disputed3. Neural inhibition has been shown to occur by the postsynaptic action of transmitter4 but at some synapses it has been established that transmission may be inhibited presynaptically5.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Kosterlitz, H. W. Handbook of Physiology section 6, IV 2147–2171 (American Physiological Society, Washington DC, 1968).

  2. Norberg, K. A., Int. J. Neuropharmac., 3, 379–382 (1964).

    Article  CAS  Google Scholar 

  3. Gershon, M. D., J. Physiol. Lond., 189, 317–327 (1967).

    Article  CAS  Google Scholar 

  4. Coombes, J. S., Eccles, J. C., and Fatt, P., J. Physiol. Lond., 130, 326–373 (1955).

    Article  Google Scholar 

  5. Dudel, J., and Kuffler, S. W., J. Physiol. Lond., 155, 543–562 (1961).

    Article  CAS  Google Scholar 

  6. Hirst, G. D. S., and McKirdy, H. C., J. Physiol. Lond., 238, 129–143 (1974).

    Article  CAS  Google Scholar 

  7. Hirst, G. D. S., Holman, M. E., and Spence, I., J. Physiol. Lond., 236, 303–326 (1974).

    Article  CAS  Google Scholar 

  8. Nishi, S., and North, F. A., J. Physiol. Lond., 231, 471–491 (1973).

    Article  CAS  Google Scholar 

  9. Finkleman, B., J. Physiol. Lond., 70, 145–157 (1930).

    Article  CAS  Google Scholar 

  10. Hirst, G. D. S., Holman, M. E., and McKirdy, H. C., J. Physiol. Lond., (in the press).

Download references

Author information

Authors and Affiliations

  1. Department of Physiology, Monash University, Clayton, Victoria, 3168, Australia

    G. D. S. HIRST & H. C. McKIRDY

Authors
  1. G. D. S. HIRST
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. C. McKIRDY
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

HIRST, G., McKIRDY, H. Presynaptic inhibition at mammalian peripheral synapse?. Nature 250, 430–431 (1974). https://doi.org/10.1038/250430a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/250430a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing