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Non-dopaminergic fibres may regulate dopamine-sensitive adenylate cyclase in the prefrontal cortex and nucleus accumbens

Abstract

The dopaminergic (DA) innervation of the prefrontal cortex in rat originates from neurones distributed in the anterior medial part of the ventral tegmental area (VTA)1. Biochemical2,3 and electrophysiological4 studies have demonstrated that these mesocortico-prefrontal neurones are distinct from others located in the VTA which project to subcortical structures such as the nucleus accumbens. DA receptors coupled to an adenylate cyclase (D-1 receptors) are present in the prefrontal cortex and their topographical distribution closely resembles that of DA nerve terminals5–7. We have now further analysed the properties of the cortical D-1 receptors and compared them with those of a subcortical limbic structure examining, in the rat, the effects on DA-sensitive adenylate cyclase activity in the prefrontal cortex and the nucleus accumbens of (1) bilateral 6-hydroxydopamine (6-OHDA) microinjections in the VTA and (2) bilateral electrolytic lesions of the VTA. The results suggest that regulation of D-1 receptors is not solely dependent on the presynaptic DA innervation and that other non-DA fibres may contribute to it.

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References

  1. Fuxe, K. et al. Brain Res. 82, 349–355 (1974).

    Article  CAS  Google Scholar 

  2. Hervé, D. et al. Neurosci. Lett. 15, 127–133 (1979).

    Article  Google Scholar 

  3. Lisoprawski, A., Hervé, D., Blanc, G., Glowinski, J. & Tassin, J. P. Brain Res. 183, 229–234 (1980).

    Article  CAS  Google Scholar 

  4. Deniau, J. M., Thierry, A. M. & Féger, J. Brain Res. 189, 315–326 (1980).

    Article  CAS  Google Scholar 

  5. Von Hungen, K. & Roberts, S. Eur. J. Biochem. 36, 391–401 (1973).

    Article  CAS  Google Scholar 

  6. Bockaert, J., Tassin, J. P., Thierry, A. M., Glowinski, J. & Prémont, J. Brain Res. 122, 71–86 (1977).

    Article  CAS  Google Scholar 

  7. Tassin, J. P. et al. Brain Res. 154, 241–251 (1978).

    Article  CAS  Google Scholar 

  8. Le Moal, M., Cardo, B. & Stinus, L. Physiol. Behav. 4, 567–573 (1969).

    Article  Google Scholar 

  9. Galey, D., Simon, M. & Le Moal, M. Brain Res. 124, 83–97 (1977).

    Article  CAS  Google Scholar 

  10. Tassin, J. P. et al. Brain Res. 141, 267–281 (1978).

    Article  CAS  Google Scholar 

  11. König, J. H. R. & Klippel, R. A. A Stereotaxic Atlas of the Forebrain and Lower Parts of the Brain Stem (William and Wilkins, Baltimore, 1963).

    Google Scholar 

  12. Gauchy, C., Tassin, J. P., Glowinski, J. & Cheramy, A. J. Neurochem. 26, 471–480 (1976).

    Article  CAS  Google Scholar 

  13. Rosenfeld, M. R., Seeger, T. F., Sharpless, N. S., Gardner, E. L. & Makman, M. H. Brain Res. 173, 572–576 (1979).

    Article  CAS  Google Scholar 

  14. Mishra, R. K., Gardner, E. L., Katzman, R. & Makman, M. H. Proc. natn. Acad. Sci. U.S.A. 71, 3883–3887 (1974).

    Article  ADS  CAS  Google Scholar 

  15. Prémont, J., Tassin, J. P., Thierry, A. M. & Glowinski, J. Expl Brain Res. 23, Suppl. 165 (1975).

    Google Scholar 

  16. Bunney, B. S. & Aghajanian, G. K. Life Sci. 19, 1783–1792 (1976).

    Article  CAS  Google Scholar 

  17. Becksteadt, R. M. J. comp. Neurol. 184, 42–43 (1979).

    Google Scholar 

  18. Pycock, C. J., Carter, C. J. & Kerwin, R. W. J. Neurochem. 34, 91–99 (1980).

    Article  CAS  Google Scholar 

  19. Ferron, A., Descarries, L. & Reader, T. A. Brain Res. 231, 93–108 (1982).

    Article  CAS  Google Scholar 

  20. Moises, H. C., Woodward, D. J., Hoffer, B. J. & Freedman, T. Expl. Neurol. 64, 493–515 (1979).

    Article  CAS  Google Scholar 

  21. Wang, R. Y., De Montigny, C., Gold, B. I., Roth, R. H. & Aghajanian, G. K. Brain Res. 178, 419–491 (1979).

    Article  Google Scholar 

  22. Krueger, B. K., Forn, J., Walters, J. R., Roth, R. H. & Greengard, P. Molec. Pharmac. 12, 639–648 (1976).

    CAS  Google Scholar 

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Tassin, J., Simon, H., Hervé, D. et al. Non-dopaminergic fibres may regulate dopamine-sensitive adenylate cyclase in the prefrontal cortex and nucleus accumbens. Nature 295, 696–698 (1982). https://doi.org/10.1038/295696a0

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