Abstract
Recently the human T cell erythrocyte receptor CD2 has been shown to bind human erythrocytes through LFA-3, a heavily gly-cosylated surface protein of broad tissue distribution1,2. CD2–LFA-3 interactions are important for cytolytic conjugate formation3,4, for thymocyte adhesion5, and for T cell activation6. A complementary DNA clone encoding LFA-3 was isolated using a novel transient expression system of mouse cells11. The cDNA encodes a phospholipid-linked membrane protein whose extracellular domain shares significant homology with CD2. As CD2 is homologous with the neural cell adhesion molecule NCAM in immunoglobulin-like domains7, cellular adhesion molecules in both neural and lymphoid tissues could have a common ancestor.
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References
Plunkett, M. L., Sanders, M. E., Selvaraj, P., Dustin, M. L. & Springer, T. A. J. exp. Med. 165, 664–676 (1987).
Selvaraj, P. et al. Nature 326, 400–403 (1987).
Krensky, A. M., Robbins, E., Springer, T. A. & Burakoff, S. J. J. Immun. 132, 2180–2182 (1984).
Shaw, S. et al. Nature 323, 262–264 (1986).
Vollger, L. W., Tuck, D. T., Springer, T. A., Haynes, B. F. & Singer, K. H. J. Immun. 138, 358–363 (1987).
Hünig, T. R., Tiefenthaler, G., Meyer zum Büschenfelde, K.-H. & Meuer, S. C. Nature 326, 298–301 (1987).
Williams, A. F. Immun. Today 8, 298–303 (1987).
Sanchez-Madrid, F. et al. Proc. natn. Acad. Sci. U.S.A. 79, 7489–7493 (1982).
Krensky, A. M. et al. J. Immun. 131, 611–616 (1983).
Dustin, M. L., Sanders, M. E., Shaw, S. & Springer, T. A. J. exp. Med. 165, 677–692 (1987).
Seed, B. & Aruffo, A. Proc. natn. Acad. Sci. U.S.A 84, 3365–3369 (1987).
van Dongen, J. J. M. et al. J. Immun. 135, 3144–3150 (1985).
Hünig, T. J. exp. Med. 162, 890–901 (1985).
Aruffo, A. & Seed, B. Proc. natn. Acad. Sci. U.S.A. (in the press).
Dailey, L. & Basilico, C. J. Virol 54, 739–749 (1985).
Barbosa, J. A. et al. J. Immun. 136, 3085–3091 (1986).
Kozak, M. Microbiol. Rev. 47, 1–45 (1983).
von Heijne, G. Nucleic Acids Res. 14, 4683–4690 (1986).
Low, M. G. & Kincade, P. A. Nature 318, 62–64 (1985).
Tse, A. G. D., Barclay, A. N., Watts, A. & Williams, A. F. Science 230, 1003–1008 (1985).
Low, M. G., Ferguson, M. A. J., Futerman, A. H. & Silman, I. Trends biochem. Sci. 11, 212–215 (1986).
Berger, J., Howard, A. D., Gerber, L., Cullen, B. R. & Udenfried, S. Proc. natn. Acad. Sci. U.S.A. 84, 4885–4889 (1987).
Sewell, W. A., Brown, M. H., Dunne, J., Owen, M. J. & Crumpton, M. J. Proc. natn. Acad. Sci. U.S.A. 83, 8718–8722 (1986).
Sayre, P. H. et al. Proc. natn. Acad. Sci. U.S.A. 84, 2941–2945 (1987).
Dayhoff, M. O., Barker, W. C. & Hunt, L. T. Meth. Enzym. 91, 524–545 (1983).
He, H. T., Barbet, J., Chaix, J. C. & Goridis, C. EMBO J. 5, 2489–2494 (1986).
Cunningham, B. A., Hemperly, J. J., Murray, B. A., Prediger, E. A., Brackenbury, R. & Edelman, G. M. Science 236, 799–806 (1987).
Peterson, A. & Seed, B. Nature 329, 842–846 (1982).
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Seed, B. An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2. Nature 329, 840–842 (1987). https://doi.org/10.1038/329840a0
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DOI: https://doi.org/10.1038/329840a0
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