Abstract
ONE of the early events in the establishment of regional diversity in brain is the subdivision of the forebrain into the cerebral cortex1–7 and underlying basal ganglia8. This subdivision is of special interest, owing to the striking difference in cellular patterning in these two regions. Whereas the dorsal aspect of the telencephalon gives rise to the laminar, cortical regions of brain, the basal aspect gives rise to nuclear, subcortical regions. To examine early events in the regionalization of the forebrain, we visualized cell movement within the ventricular zones of the dorsal and basal regions of the E15 murine telencephalon. Over an 8–24-hour observation period, labelled cells moved extensively in the plane of the cortical ventricular zone. Cell dispersion was restricted, however, at the border between the cortical ventricular zone and the lateral ganglionic eminence, the basal telencephalic ventricular zone. We suggest that this restriction of cell movements establishes a regional pattern of neurogenesis in the developing brain.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Ramon Cajal, S. Histologie du Systeme Neneux de I'Homme et des Vertebres Vol. II (Maloine, Paris, 1911).
Sauer, F. C. J. comp. Neurol. 63, 13–23 (1935).
Sauer, M. E. & Chittenden, A. C. Proc. Soc. exp. Biot. Med. 101, 557–560 (1959).
Rakic, P. J. comp. Neurol. 141, 283–312 (1971).
Sidman, R. L. & Rakic, P. Brain Res. 62, 1–35 (1973).
Berry, M. & Rogers, A. W. J. Anat. 99, 691–709 (1965).
The Boulder Committee Anat Rec. 166, 257–262 (1970).
Smart, I. H. M. & Sturrock, R. R. Ontogeny of the Neostriatum 23, 127–146 (1979).
Honig, M. C. & Hume, R. I. Trends Neurosci. 12, 333–341 (1989).
Friederikson, K. & McKay, R. J. Neurosci. 58, 815–821 (1988).
Mission, J.-P., Takahashi, R. & Caviness, V. S. Glia 4, 138–148 (1991).
Edmondson, J. C. & Hatten, M. E. J. Neurosci. 7, 1928–1934 (1987).
Godemont, P., Salaun, J. & Mason, C. A. Neuron 5, 173–186 (1990).
Gruler, H. & Bultmann, B. D. Blood Cells 10, 61–77 (1984).
Walsh, C. & Cepko, C. L. Soc. Neurosci. Abstr. 18, 925 (1992).
Luskin, M. B., Pearlman, A. L. & Sanes, J. R. Neuron 1, 635–647 (1988).
Price, J. & Thurlow, L. Development 104, 473–482 (1988).
Walsh, C. & Cepko, C. L. Science 241, 1342–1345 (1988).
Walsh, C. & Cepko, C. L. Science 255, 434–440 (1992).
Misson, J. P., Austin, C. P., Takahashi, T., Cepko, C. L. & Caviness, V. S. Cerebral Cortex 1, 221–234 (1991).
Gray, G. E. & Sanes, J. R. Neuron 6, 211–225 (1992).
O'Rourke, N. A., Dailey, M. E., Smith, S. J. & McConnell, S. K. Science 258, 299–302 (1992).
Porteus, M. H., Bulfone, A., Ciarnello, R. D. & Rubenstein, J. L. R. Neuron 7, 221–229 (1991).
Tao, W. & Lai, E. Neuron 8, 957–966 (1992).
Price, M., Lemaistre, M., Pischetola, M., Di Lauro, R. & Duboule, D. Nature 351, 748–751 (1991).
Lo, L.-C. et al. Genes Dev. 5, 1524–1537 (1991).
Simeone, A. et al. Nature 358, 687–690 (1992).
Fraser, S., Keynes, R. & Lumsden, A. Nature 344, 431–435 (1990).
McGinnis, W. & Krumlauf, R. Cell 68, 283–302 (1992).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Fishell, G., Mason, C. & Hatten, M. Dispersion of neural progenitors within the germinal zones of the forebrain. Nature 362, 636–638 (1993). https://doi.org/10.1038/362636a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/362636a0
This article is cited by
-
Characterization of neurogenic niches in the telencephalon of juvenile and adult sharks
Brain Structure and Function (2020)
-
Role of NMDA receptors in adult neurogenesis: an ontogenetic (re)view on activity-dependent development
Cellular and Molecular Life Sciences (2013)
-
Reactive oxygen species and the neuronal fate
Cellular and Molecular Life Sciences (2012)
-
Compartment-specific transcription factors orchestrate angiogenesis gradients in the embryonic brain
Nature Neuroscience (2008)
-
Compartments and their boundaries in vertebrate brain development
Nature Reviews Neuroscience (2005)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.