Abstract
POSTSYNAPTIC Ca2+ elevation during synaptic transmission is an important trigger for short- and long-term changes in synaptic strength in the vertebrate central nervous system1. The AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazoleproprionate) receptors, a subfamily of glutamate receptors, mediate much of the excitatory synaptic transmission in the brain and spinal cord2. It has been shown that a subtype of the AMPA receptor is Ca2+-permeable3–6 and is present in subpopulations of neurons7–12. When synaptically localized13, these receptors should mediate postsynaptic Ca2+ influx, providing a trigger for changes in synaptic strength. Here we show that Ca2+-permeable AMPA receptors are synaptically localized on a subpopulation of dorsal horn neurons, that they provide a synaptically gated route of Ca2+ entry, and that activation of these receptors strengthens synaptic transmission mediated by AMPA receptors. This pathway for postsynaptic Ca2+ influx may provide a new form of activity-dependent modulation of synaptic strength.
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Gu, J., Albuquerque, C., Lee, C. et al. Synaptic strengthening through activation of Ca2+ -permeable AMPA receptors. Nature 381, 793–796 (1996). https://doi.org/10.1038/381793a0
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DOI: https://doi.org/10.1038/381793a0
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