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Apoptosis

Stabbed in the BAX

Nature volume 455, pages 1047–1049 (2008)Cite this article

Apoptotic cell death is an intricate and highly regulated process. To initiate apoptosis, the protein BIM binds to a hitherto unrecognized site on the BAX protein to trigger permeabilization of the outer mitochondrial membrane.

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Figure 1: Activation of the BAX protein by the BIM SAHB domain.
Figure 2: Possible consequences of BIM SAHB binding to BAX.

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Authors and Affiliations

  1. Douglas R. Green and Jerry E. Chipuk are in the Department of Immunology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA. douglas.green@stjude.org,

    Douglas R. Green & Jerry E. Chipuk

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  1. Douglas R. Green
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  2. Jerry E. Chipuk
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Green, D., Chipuk, J. Stabbed in the BAX. Nature 455, 1047–1049 (2008). https://doi.org/10.1038/4551047a

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