Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Turbocharging neurons for growth: accelerating regeneration in the adult CNS

Mature central neurons lose their capacity for axon growth, but overexpression of growth-associated proteins restores this potential, which may support spinal cord regeneration.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Large-caliber, low-threshold mechanosensory neurons have their cell bodies in the dorsal root ganglion, a peripheral axon innervating skin muscle and joints, and a central axon that runs up the dorsal columns in the spinal cord to the brain stem.

Bob Crimi

References

  1. Bomze, H. M, Bulsara, K. R., Iskandar, B. J., Caroni, P. & Skene, J. H. P. Nat. Neurosci. 4, 38–43 (2001).

    Article  CAS  Google Scholar 

  2. Skene, J. H. P. Annu. Rev. Neurosci. 12, 127–156 (1989).

    Article  CAS  Google Scholar 

  3. Wiederkehr, A., Staple, J. & Caroni, P. Exp.Cell Res. 236, 103–116 (1997).

    Article  CAS  Google Scholar 

  4. Bashaw, G. J. & Goodman, C. S. Cell 97, 917–926 (1999).

    Article  CAS  Google Scholar 

  5. Goldberg, J. L. & Barres, B. A. Nature 403, 369–370 (2000).

    Article  CAS  Google Scholar 

  6. Ramon-Cueto, A., Cordero, M. I., Santos-Benito, F. F. & Avila, J. Neuron 25, 425–435 (2000).

    Article  CAS  Google Scholar 

  7. Skene, J. H. P. & Willard, M. A. J.Cell Biol. 89, 96–103 (1981).

    Article  CAS  Google Scholar 

  8. Richardson, P. M. & Issa, V. M. K. Nature 309, 791–793 (1984).

    Article  CAS  Google Scholar 

  9. Neumann, S. & Woolf, C. J. Neuron 23, 83–91 (1999).

    Article  CAS  Google Scholar 

  10. Chong, M.-S. et al. J. Neurosci. 14, 4375–4384 (1994).

    Article  CAS  Google Scholar 

  11. Schreyer, D. J. & Skene, J. H. P. J. Neurobiol. 24, 959–970 (1993).

    Article  CAS  Google Scholar 

  12. Schreyer, D. J. & Skene, J. H. P. J. Neurosci. 11, 3738–3451 (1991).

    Article  CAS  Google Scholar 

  13. Hu-Tsai, M., Woolf, C. J., Emson, P. C. & Winter, J. J. Neurosci. Res. 39, 634–645 (1994).

    Article  CAS  Google Scholar 

  14. Strittmatter, S. M., Fannkhouser, C., Huang, P. L., Mashius, H. & Fishman, M. C. Cell 80, 445–452 (1995).

    Article  CAS  Google Scholar 

  15. Buffo, A. et al. J. Neurosci. 17, 8778–8791 (1997).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Woolf, C. Turbocharging neurons for growth: accelerating regeneration in the adult CNS. Nat Neurosci 4, 7–9 (2001). https://doi.org/10.1038/82921

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/82921

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing