Integrins are receptors for extracellular matrix proteins that engage in reciprocal crosstalk with growth factor receptors. Recent work identifies a unique mechanism for the regulation of growth factor receptor phosphorylation by integrins, indicating multiple ways of achieving cooperation between these major signalling systems.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
FGFR2 Controls Growth, Adhesion and Migration of Nontumorigenic Human Mammary Epithelial Cells by Regulation of Integrin β1 Degradation
Journal of Mammary Gland Biology and Neoplasia Open Access 16 May 2023
-
Extracellular matrix dynamics: tracking in biological systems and their implications
Journal of Biological Engineering Open Access 30 May 2022
-
RETRACTED ARTICLE: Receptor tyrosine kinase inhibitor Sunitinib and integrin antagonist peptide HM-3 show similar lipid raft dependent biphasic regulation of tumor angiogenesis and metastasis
Journal of Experimental & Clinical Cancer Research Open Access 28 August 2019
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Schwartz, M. A. & Baron, V. Curr. Opin. Cell Biol. 11, 197–202 (1999).
Yamada, K. M. & Danen, E. H. J. Integrin signalling. In Signalling Networks and Cell Cycle Control (ed. Gutkind, J. S.) 1–25 (Humana Press, Totowa, NJ, 2000).
Moro, L. et al. J. Biol. Chem. 277, 9405–9414 (2002).
Schlessinger, J. Cell 103, 211–225 (2000).
Miyamoto, S., Teramoto, H., Gutkind, J. S. & Yamada, K. M. J. Cell Biol. 135, 1633–1642 (1996).
Sundberg, C. & Rubin, K. J. Cell Biol. 132, 741–572 (1996).
Wang, R., Kobayashi, R. & Bishop, J. M. Proc. Natl Acad. Sci. USA 93, 8425–8430 (1996).
Moro, L. et al. EMBO J. 17, 6622–6632 (1998).
Wang, J. F., Zhang, X. F. & Groopman, J. E. J. Biol. Chem. 276, 41950–41957 (2001).
Danilkovitch-Miagkova, A. et al. J. Biol. Chem. 275, 14783–14786 (2000).
Ivankovic-Dikic, I., Gronroos, E., Blaukat, A., Barth, B. U. & Dikic, I. Nature Cell Biol. 2, 574–581 (2000).
Sieg, D. J. et al. Nature Cell Biol. 2, 249–256 (2000).
Pece, S. & Gutkind, J. S. J. Biol. Chem. 275, 41227–41233 (2000).
Luttrell, L. M., Daaka, Y. & Lefkowitz, R. J. Curr. Opin. Cell Biol. 11, 177–83 (1999).
Daub, H., Weiss, F. U., Wallasch, C. & Ullrich, A. Nature 379, 557–60 (1996).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Yamada, K., Even-Ram, S. Integrin regulation of growth factor receptors. Nat Cell Biol 4, E75–E76 (2002). https://doi.org/10.1038/ncb0402-e75
Issue Date:
DOI: https://doi.org/10.1038/ncb0402-e75
This article is cited by
-
FGFR2 Controls Growth, Adhesion and Migration of Nontumorigenic Human Mammary Epithelial Cells by Regulation of Integrin β1 Degradation
Journal of Mammary Gland Biology and Neoplasia (2023)
-
Extracellular matrix dynamics: tracking in biological systems and their implications
Journal of Biological Engineering (2022)
-
EGFR inhibitor AG1478 blocks the formation of 3D structures mainly through ERK signaling pathway in Matrigel-induced 3D reconstruction of eccrine sweat gland-like structures
Journal of Molecular Histology (2020)
-
RETRACTED ARTICLE: Receptor tyrosine kinase inhibitor Sunitinib and integrin antagonist peptide HM-3 show similar lipid raft dependent biphasic regulation of tumor angiogenesis and metastasis
Journal of Experimental & Clinical Cancer Research (2019)
-
Integrin-EGFR interaction regulates anoikis resistance in colon cancer cells
Apoptosis (2019)