Inhibitory neurotransmission by γ-aminobutyric acid (GABA) is regulated by the number and subcellular localization of GABAA receptors in the membrane of the target neuron. A new study suggests that the ubiquitin-like protein Plic-1 stabilizes intracellular GABAA receptors and promotes their accumulation in the plasma membrane.
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Lüscher, B., Keller, C. Ubiquitination, proteasomes and GABAA receptors. Nat Cell Biol 3, E232–E233 (2001). https://doi.org/10.1038/ncb1001-e232
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DOI: https://doi.org/10.1038/ncb1001-e232