Abstract
In animals such as the fruitfly, even minor deviations in environmental temperature can have major impacts on development and lifespan. Here we demonstrated that the ability of Drosophila melanogaster larvae to discriminate between the optimal temperature of 18 °C and slightly higher temperatures (19–24 °C) depended on the TRPA1 channel, which functioned downstream of a phospholipase C–dependent signaling cascade similar to that used in fly phototransduction. We propose that activation of TRPA1 through a signaling cascade promotes amplification of small differences in temperature and facilitates adaptation to temperatures within the comfortable range.
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Acknowledgements
This work is dedicated to the memory of Bae Gyo Jung. We thank M.-K. Chung for helpful suggestions. This work was supported by grants from the US National Eye Institute (EY010852) and US National Institute of General Medical Sciences (GM085335).
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Y.K. and C.M. designed the experimental plan, analyzed the data and prepared the manuscript. C.M. also supervised the research and obtained the funding for this study. Y.K. and H.-S.S. conducted the behavioral assays. Y.K. also generated the trpA11 mutant and performed the GFP localization studies. X.W. generated the wtrw1 mutant. H.-S.S. and X.W. also helped analyze the data and improved the manuscript with their comments.
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Supplementary Figures 1–4, Supplementary Tables 1–9 and Supplementary Methods (PDF 3454 kb)
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Kwon, Y., Shim, HS., Wang, X. et al. Control of thermotactic behavior via coupling of a TRP channel to a phospholipase C signaling cascade. Nat Neurosci 11, 871–873 (2008). https://doi.org/10.1038/nn.2170
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DOI: https://doi.org/10.1038/nn.2170
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