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Developmentally degraded cortical temporal processing restored by training

Abstract

Enduring deficits in temporal processing can be induced in the auditory cortex by rearing infant rats in the presence of low frequency–modulated noises. We found that it was possible to restore normal temporal processing, overcoming deficits induced during the critical period, by intensively training developmentally impaired animals as juveniles or young adults. Re-normalized cortical temporal response characteristics were sustained long after training cessation.

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Figure 1: Learning a temporal rate–discrimination task.
Figure 2: Cortical temporal responses for different groups of rats.

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References

  1. Dahmen, J.C. & King, A.J. Curr. Opin. Neurobiol. 17, 456–464 (2007).

    Article  CAS  Google Scholar 

  2. Zhang, L.I., Bao, S. & Merzenich, M.M. Proc. Natl. Acad. Sci. USA 99, 2309–2314 (2002).

    Article  CAS  Google Scholar 

  3. Zhou, X. & Merzenich, M.M. Proc. Natl. Acad. Sci. USA 105, 4423–4428 (2008).

    Article  CAS  Google Scholar 

  4. Joris, P.X., Schreiner, C.E. & Rees, A. Physiol. Rev. 84, 541–577 (2004).

    Article  CAS  Google Scholar 

  5. Fitch, R.H. & Tallal, P. Behav. Cogn. Neurosci. Rev. 2, 155–178 (2003).

    Article  Google Scholar 

  6. Wright, B.A. et al. Nature 387, 176–178 (1997).

    Article  CAS  Google Scholar 

  7. Bao, S., Chang, E.F., Woods, J. & Merzenich, M.M. Nat. Neurosci. 7, 974–981 (2004).

    Article  CAS  Google Scholar 

  8. Beitel, R.E., Schreiner, C.E., Cheung, S.W., Wang, X. & Merzenich, M.M. Proc. Natl. Acad. Sci. USA 100, 11070–11075 (2003).

    Article  CAS  Google Scholar 

  9. van Wassenhove, V. & Nagarajan, S.S. J. Neurosci. 27, 2663–2672 (2007).

    Article  CAS  Google Scholar 

  10. Polley, D.B., Steinberg, E.E. & Merzenich, M.M. J. Neurosci. 26, 4970–4982 (2006).

    Article  CAS  Google Scholar 

  11. Markram, H. & Tsodyks, M. Nature 382, 807–810 (1996).

    Article  CAS  Google Scholar 

  12. Mauk, M.D. & Buonomano, D.V. Annu. Rev. Neurosci. 27, 307–340 (2004).

    Article  CAS  Google Scholar 

  13. Merzenich, M.M. et al. Science 271, 77–81 (1996).

    Article  CAS  Google Scholar 

  14. Tallal, P. et al. Science 271, 81–84 (1996).

    Article  CAS  Google Scholar 

  15. Zhou, X. & Merzenich, M.M. Proc. Natl. Acad. Sci. USA 104, 15935–15940 (2007).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We thank C.E. Schreiner, C.M. Niell, L. Wilbrecht, M.P. Stryker, R.C. Froemke and T. Babcock for helpful comments on the manuscript. This work was supported by US National Institutes of Health grants MH77970 and NS34835, the Sandler Fund, the Coleman Fund, the Shanghai Rising-Star Program (05QMX1420) and matching fund from the East China Normal University.

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Contributions

X.Z. conducted the experiments. X.Z. and M.M.M. designed the experiments, analyzed the data and wrote the manuscript.

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Correspondence to Xiaoming Zhou.

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Supplementary Figures 1–4 and Supplementary Methods (PDF 331 kb)

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Zhou, X., Merzenich, M. Developmentally degraded cortical temporal processing restored by training. Nat Neurosci 12, 26–28 (2009). https://doi.org/10.1038/nn.2239

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