Abstract
Using two photon–guided focal stimulation, we found spike timing–dependent plasticity of proximal excitatory inputs to olfactory bulb granule cells that originated, in part, from cortical feedback projections. The protocol that potentiated proximal inputs depressed distal, dendrodendritic inputs to granule cells. Granule cell excitatory postsynaptic potentials and mitral cell inhibition were also potentiated by theta-burst stimulation. Plasticity of cortical feedback inputs to interneurons provides a mechanism for encoding information by modulating bulbar inhibition.
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References
Bruce, H.M. Nature 184, 105 (1959).
Brennan, P.A. & Keverne, E.B. Prog. Neurobiol. 51, 457–481 (1997).
Lévy, F. et al. Behav. Neurosci. 104, 464–469 (1990).
Kendrick, K.M., Lévy, F. & Keverne, E.B. Science 256, 833–836 (1992).
Wilson, D.A., Sullivan, R.M. & Leon, M. Brain Res. 354, 314–317 (1985).
Satou, M., Anzai, S. & Huruno, M. J. Comp. Physiol. A Neuroethol. Sens. Neural. Behav. Physiol. 191, 421–434 (2005).
Haberly, L.B. & Price, J.L. J. Comp. Neurol. 178, 711–740 (1978).
Balu, R., Pressler, R.T. & Strowbridge, B.W. J. Neurosci. 27, 5621–5632 (2007).
Sjöström, P.J. & Häusser, M. Neuron 51, 227–238 (2006).
Zibrowski, E.M. & Vanderwolf, C.H. Brain Res. 766, 39–49 (1997).
Neville, K.R. & Haberly, L.B. J. Neurophysiol. 90, 3921–3930 (2003).
Ravel, N. et al. Eur. J. Neurosci. 17, 350–358 (2003).
Isaacson, J.S. & Strowbridge, B.W. Neuron 20, 749–761 (1998).
Schoppa, N.E. et al. J. Neurosci. 18, 6790–6802 (1998).
Halabisky, B. & Strowbridge, B.W. J. Neurophysiol. 90, 644–654 (2003).
Acknowledgements
We thank T. Pressler and P. Larimer for helpful discussions and constructive comments on this manuscript. This work was supported by US National Institutes of Health grant R01-DC04285 to B.W.S.
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Y.G. and B.W.S. designed the experiments, analyzed the data and wrote the manuscript. Y.G. conducted the experiments.
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Gao, Y., Strowbridge, B. Long-term plasticity of excitatory inputs to granule cells in the rat olfactory bulb. Nat Neurosci 12, 731–733 (2009). https://doi.org/10.1038/nn.2319
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DOI: https://doi.org/10.1038/nn.2319
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