Neurons adapt to sustained alterations in activity by changing their intrinsic excitability. A form of this plasticity in hippocampal pyramidal neurons involves calcineurin-dependent dispersion and change in gating of K+ channels, reducing the cell's excitability.
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Surmeier, D., Foehring, R. A mechanism for homeostatic plasticity. Nat Neurosci 7, 691–692 (2004). https://doi.org/10.1038/nn0704-691
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DOI: https://doi.org/10.1038/nn0704-691
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