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Doublecortin finds its place

Confusing results from gene deletion experiments have left the importance of doublecortin (DCX) during brain development unclear. A report in this issue establishes a definitive function for DCX and highlights limitations of gene knockout approaches.

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Figure 1: The 'double cortex' mutation.

Erin Boyle

Figure 2: Migration defects in the embryonic rat after Dcx RNA interference.

Erin Boyle

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Götz, M. Doublecortin finds its place. Nat Neurosci 6, 1245–1247 (2003). https://doi.org/10.1038/nn1203-1245

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